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Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species

In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction could define the balance betwee...

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Autores principales: Calvani, Maura, Pasha, Amada, Favre, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139678/
https://www.ncbi.nlm.nih.gov/pubmed/32178382
http://dx.doi.org/10.3390/ijms21061936
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author Calvani, Maura
Pasha, Amada
Favre, Claudio
author_facet Calvani, Maura
Pasha, Amada
Favre, Claudio
author_sort Calvani, Maura
collection PubMed
description In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction could define the balance between health and disease. Nutrients and dietary components influence epigenetic phenomena and modify drugs response; therefore, these food–host interactions can influence the individual predisposition to disease and its potential therapeutic response. Do nutraceuticals have positive or negative effects during chemotherapy? The use of nutraceutical supplements in cancer patients is a controversial debate without a definitive conclusion to date. During cancer treatment, patients take nutraceuticals to alleviate drug toxicity and improve long-term results. Some nutraceuticals may potentiate the effect of cytotoxic chemotherapy by inducing cell growth arrest, cell differentiation, and alteration of the redox state of cells, but in some cases, high levels of them may interfere with the effectiveness of chemotherapy, making cancer cells less reactive to chemotherapy. In this review, we highlighted the emerging opinions and data on the pros and cons on the use of nutraceutical supplements during chemotherapy.
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spelling pubmed-71396782020-04-10 Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species Calvani, Maura Pasha, Amada Favre, Claudio Int J Mol Sci Review In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction could define the balance between health and disease. Nutrients and dietary components influence epigenetic phenomena and modify drugs response; therefore, these food–host interactions can influence the individual predisposition to disease and its potential therapeutic response. Do nutraceuticals have positive or negative effects during chemotherapy? The use of nutraceutical supplements in cancer patients is a controversial debate without a definitive conclusion to date. During cancer treatment, patients take nutraceuticals to alleviate drug toxicity and improve long-term results. Some nutraceuticals may potentiate the effect of cytotoxic chemotherapy by inducing cell growth arrest, cell differentiation, and alteration of the redox state of cells, but in some cases, high levels of them may interfere with the effectiveness of chemotherapy, making cancer cells less reactive to chemotherapy. In this review, we highlighted the emerging opinions and data on the pros and cons on the use of nutraceutical supplements during chemotherapy. MDPI 2020-03-12 /pmc/articles/PMC7139678/ /pubmed/32178382 http://dx.doi.org/10.3390/ijms21061936 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Calvani, Maura
Pasha, Amada
Favre, Claudio
Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
title Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
title_full Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
title_fullStr Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
title_full_unstemmed Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
title_short Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species
title_sort nutraceutical boom in cancer: inside the labyrinth of reactive oxygen species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139678/
https://www.ncbi.nlm.nih.gov/pubmed/32178382
http://dx.doi.org/10.3390/ijms21061936
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