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Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells

To produce the wide range of blood and immune cell types, haematopoietic stem cells can “choose” directly from the entire spectrum of blood cell fate-options. Affiliation to a single cell lineage can occur at the level of the haematopoietic stem cell and these cells are therefore a mixture of some p...

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Autores principales: Brown, Geoffrey, Sánchez, Lucía, Sánchez-García, Isidro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139697/
https://www.ncbi.nlm.nih.gov/pubmed/32213936
http://dx.doi.org/10.3390/ijms21062247
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author Brown, Geoffrey
Sánchez, Lucía
Sánchez-García, Isidro
author_facet Brown, Geoffrey
Sánchez, Lucía
Sánchez-García, Isidro
author_sort Brown, Geoffrey
collection PubMed
description To produce the wide range of blood and immune cell types, haematopoietic stem cells can “choose” directly from the entire spectrum of blood cell fate-options. Affiliation to a single cell lineage can occur at the level of the haematopoietic stem cell and these cells are therefore a mixture of some pluripotent cells and many cells with lineage signatures. Even so, haematopoietic stem cells and their progeny that have chosen a particular fate can still “change their mind” and adopt a different developmental pathway. Many of the leukaemias arise in haematopoietic stem cells with the bulk of the often partially differentiated leukaemia cells belonging to just one cell type. We argue that the reason for this is that an oncogenic insult to the genome “hard wires” leukaemia stem cells, either through development or at some stage, to one cell lineage. Unlike normal haematopoietic stem cells, oncogene-transformed leukaemia stem cells and their progeny are unable to adopt an alternative pathway.
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spelling pubmed-71396972020-04-10 Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells Brown, Geoffrey Sánchez, Lucía Sánchez-García, Isidro Int J Mol Sci Review To produce the wide range of blood and immune cell types, haematopoietic stem cells can “choose” directly from the entire spectrum of blood cell fate-options. Affiliation to a single cell lineage can occur at the level of the haematopoietic stem cell and these cells are therefore a mixture of some pluripotent cells and many cells with lineage signatures. Even so, haematopoietic stem cells and their progeny that have chosen a particular fate can still “change their mind” and adopt a different developmental pathway. Many of the leukaemias arise in haematopoietic stem cells with the bulk of the often partially differentiated leukaemia cells belonging to just one cell type. We argue that the reason for this is that an oncogenic insult to the genome “hard wires” leukaemia stem cells, either through development or at some stage, to one cell lineage. Unlike normal haematopoietic stem cells, oncogene-transformed leukaemia stem cells and their progeny are unable to adopt an alternative pathway. MDPI 2020-03-24 /pmc/articles/PMC7139697/ /pubmed/32213936 http://dx.doi.org/10.3390/ijms21062247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brown, Geoffrey
Sánchez, Lucía
Sánchez-García, Isidro
Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells
title Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells
title_full Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells
title_fullStr Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells
title_full_unstemmed Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells
title_short Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells
title_sort lineage decision-making within normal haematopoietic and leukemic stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139697/
https://www.ncbi.nlm.nih.gov/pubmed/32213936
http://dx.doi.org/10.3390/ijms21062247
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