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Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer
This study aimed to first elucidate prostate-specific antigen (PSA) kinetics in prostate cancer patients treated with carbon ion radiotherapy (CIRT). From 2010 to 2015, 131 patients with prostate adenocarcinoma treated with CIRT (57.6 Gy relative biological effectiveness (RBE) in 16 fractions) alone...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139713/ https://www.ncbi.nlm.nih.gov/pubmed/32143495 http://dx.doi.org/10.3390/cancers12030589 |
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author | Darwis, Narisa Dewi Maulany Oike, Takahiro Kawamura, Hidemasa Kawahara, Masahiro Kubo, Nobuteru Sato, Hiro Miyasaka, Yuhei Katoh, Hiroyuki Ishikawa, Hitoshi Matsui, Hiroshi Miyazawa, Yoshiyuki Ito, Kazuto Suzuki, Kazuhiro Gondhowiardjo, Soehartati Nakano, Takashi Ohno, Tatsuya |
author_facet | Darwis, Narisa Dewi Maulany Oike, Takahiro Kawamura, Hidemasa Kawahara, Masahiro Kubo, Nobuteru Sato, Hiro Miyasaka, Yuhei Katoh, Hiroyuki Ishikawa, Hitoshi Matsui, Hiroshi Miyazawa, Yoshiyuki Ito, Kazuto Suzuki, Kazuhiro Gondhowiardjo, Soehartati Nakano, Takashi Ohno, Tatsuya |
author_sort | Darwis, Narisa Dewi Maulany |
collection | PubMed |
description | This study aimed to first elucidate prostate-specific antigen (PSA) kinetics in prostate cancer patients treated with carbon ion radiotherapy (CIRT). From 2010 to 2015, 131 patients with prostate adenocarcinoma treated with CIRT (57.6 Gy relative biological effectiveness (RBE) in 16 fractions) alone were recruited. PSA was measured at 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 months post-CIRT. PSA bounce was defined as PSA increase over a cutoff followed by spontaneous decrease to or below the pre-bounce nadir. PSA failure was determined using the Phoenix criteria (nadir + 2.0 ng/mL). As a result, non-failure-associated temporary increase in PSA exhibited two distinct patterns, namely a classical bounce and a surge at one month. PSA bounce of ≥0.2 ng/mL was observed in 55.7% of the patients. Bounce amplitude was <2.0 ng/mL in 97.6% of cases. Bounce occurred significantly earlier than PSA failure. Younger age was a significant predictor of bounce occurrence. Bounce positivity was a significant predictor of favorable 5-year PSA failure-free survival. Meanwhile, a PSA surge of ≥0.2 ng/mL was observed in 67.9% of patients. Surge amplitude was significantly larger than bounce amplitude. Larger prostate volume was a significant predictor of PSA surge occurrence. PSA surge positivity did not significantly predict PSA failure. In summary, PSA bounce was distinguishable from PSA failure with regard to timing of occurrence and amplitude (earlier and lower for bounce, respectively). These data are useful for post-CIRT surveillance of prostate cancer patients. |
format | Online Article Text |
id | pubmed-7139713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71397132020-04-10 Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer Darwis, Narisa Dewi Maulany Oike, Takahiro Kawamura, Hidemasa Kawahara, Masahiro Kubo, Nobuteru Sato, Hiro Miyasaka, Yuhei Katoh, Hiroyuki Ishikawa, Hitoshi Matsui, Hiroshi Miyazawa, Yoshiyuki Ito, Kazuto Suzuki, Kazuhiro Gondhowiardjo, Soehartati Nakano, Takashi Ohno, Tatsuya Cancers (Basel) Article This study aimed to first elucidate prostate-specific antigen (PSA) kinetics in prostate cancer patients treated with carbon ion radiotherapy (CIRT). From 2010 to 2015, 131 patients with prostate adenocarcinoma treated with CIRT (57.6 Gy relative biological effectiveness (RBE) in 16 fractions) alone were recruited. PSA was measured at 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 months post-CIRT. PSA bounce was defined as PSA increase over a cutoff followed by spontaneous decrease to or below the pre-bounce nadir. PSA failure was determined using the Phoenix criteria (nadir + 2.0 ng/mL). As a result, non-failure-associated temporary increase in PSA exhibited two distinct patterns, namely a classical bounce and a surge at one month. PSA bounce of ≥0.2 ng/mL was observed in 55.7% of the patients. Bounce amplitude was <2.0 ng/mL in 97.6% of cases. Bounce occurred significantly earlier than PSA failure. Younger age was a significant predictor of bounce occurrence. Bounce positivity was a significant predictor of favorable 5-year PSA failure-free survival. Meanwhile, a PSA surge of ≥0.2 ng/mL was observed in 67.9% of patients. Surge amplitude was significantly larger than bounce amplitude. Larger prostate volume was a significant predictor of PSA surge occurrence. PSA surge positivity did not significantly predict PSA failure. In summary, PSA bounce was distinguishable from PSA failure with regard to timing of occurrence and amplitude (earlier and lower for bounce, respectively). These data are useful for post-CIRT surveillance of prostate cancer patients. MDPI 2020-03-04 /pmc/articles/PMC7139713/ /pubmed/32143495 http://dx.doi.org/10.3390/cancers12030589 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Darwis, Narisa Dewi Maulany Oike, Takahiro Kawamura, Hidemasa Kawahara, Masahiro Kubo, Nobuteru Sato, Hiro Miyasaka, Yuhei Katoh, Hiroyuki Ishikawa, Hitoshi Matsui, Hiroshi Miyazawa, Yoshiyuki Ito, Kazuto Suzuki, Kazuhiro Gondhowiardjo, Soehartati Nakano, Takashi Ohno, Tatsuya Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer |
title | Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer |
title_full | Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer |
title_fullStr | Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer |
title_full_unstemmed | Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer |
title_short | Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer |
title_sort | kinetics of prostate-specific antigen after carbon ion radiotherapy for prostate cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139713/ https://www.ncbi.nlm.nih.gov/pubmed/32143495 http://dx.doi.org/10.3390/cancers12030589 |
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