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The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections
Autophagy is a general protective mechanism for maintaining homeostasis in eukaryotic cells, regulating cellular metabolism, and promoting cell survival by degrading and recycling cellular components under stress conditions. The degradation pathway that is mediated by autophagy receptors is called s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139735/ https://www.ncbi.nlm.nih.gov/pubmed/32187990 http://dx.doi.org/10.3390/ijms21062008 |
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author | Fan, Shuangqi Wu, Keke Zhao, Mengpo Zhu, Erpeng Ma, Shengming Chen, Yuming Ding, Hongxing Yi, Lin Zhao, Mingqiu Chen, Jinding |
author_facet | Fan, Shuangqi Wu, Keke Zhao, Mengpo Zhu, Erpeng Ma, Shengming Chen, Yuming Ding, Hongxing Yi, Lin Zhao, Mingqiu Chen, Jinding |
author_sort | Fan, Shuangqi |
collection | PubMed |
description | Autophagy is a general protective mechanism for maintaining homeostasis in eukaryotic cells, regulating cellular metabolism, and promoting cell survival by degrading and recycling cellular components under stress conditions. The degradation pathway that is mediated by autophagy receptors is called selective autophagy, also named as xenophagy. Autophagy receptor NDP52 acts as a ‘bridge’ between autophagy and the ubiquitin-proteasome system, and it also plays an important role in the process of selective autophagy. Pathogenic microbial infections cause various diseases in both humans and animals, posing a great threat to public health. Increasing evidence has revealed that autophagy and autophagy receptors are involved in the life cycle of pathogenic microbial infections. The interaction between autophagy receptor and pathogenic microorganism not only affects the replication of these microorganisms in the host cell, but it also affects the host’s immune system. This review aims to discuss the effects of autophagy on pathogenic microbial infection and replication, and summarizes the mechanisms by which autophagy receptors interact with microorganisms. While considering the role of autophagy receptors in microbial infection, NDP52 might be a potential target for developing effective therapies to treat pathogenic microbial infections. |
format | Online Article Text |
id | pubmed-7139735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71397352020-04-10 The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections Fan, Shuangqi Wu, Keke Zhao, Mengpo Zhu, Erpeng Ma, Shengming Chen, Yuming Ding, Hongxing Yi, Lin Zhao, Mingqiu Chen, Jinding Int J Mol Sci Review Autophagy is a general protective mechanism for maintaining homeostasis in eukaryotic cells, regulating cellular metabolism, and promoting cell survival by degrading and recycling cellular components under stress conditions. The degradation pathway that is mediated by autophagy receptors is called selective autophagy, also named as xenophagy. Autophagy receptor NDP52 acts as a ‘bridge’ between autophagy and the ubiquitin-proteasome system, and it also plays an important role in the process of selective autophagy. Pathogenic microbial infections cause various diseases in both humans and animals, posing a great threat to public health. Increasing evidence has revealed that autophagy and autophagy receptors are involved in the life cycle of pathogenic microbial infections. The interaction between autophagy receptor and pathogenic microorganism not only affects the replication of these microorganisms in the host cell, but it also affects the host’s immune system. This review aims to discuss the effects of autophagy on pathogenic microbial infection and replication, and summarizes the mechanisms by which autophagy receptors interact with microorganisms. While considering the role of autophagy receptors in microbial infection, NDP52 might be a potential target for developing effective therapies to treat pathogenic microbial infections. MDPI 2020-03-16 /pmc/articles/PMC7139735/ /pubmed/32187990 http://dx.doi.org/10.3390/ijms21062008 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fan, Shuangqi Wu, Keke Zhao, Mengpo Zhu, Erpeng Ma, Shengming Chen, Yuming Ding, Hongxing Yi, Lin Zhao, Mingqiu Chen, Jinding The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections |
title | The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections |
title_full | The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections |
title_fullStr | The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections |
title_full_unstemmed | The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections |
title_short | The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections |
title_sort | role of autophagy and autophagy receptor ndp52 in microbial infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139735/ https://www.ncbi.nlm.nih.gov/pubmed/32187990 http://dx.doi.org/10.3390/ijms21062008 |
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