Cargando…

Sustained Release of Decoy Wnt Receptor (sLRP6E1E2)-Expressing Adenovirus Using Gel-Encapsulation for Scar Remodeling in Pig Model

An adenoviral vector (Ad) expressing a Wnt decoy receptor (sLRP6E1E2) is known to induce an anti-fibrotic effect by inhibiting Wnt signaling. We evaluated its effects in vivo using pig models and attempted to introduce an alginate gel-matrix system to prolong the effect of the Ad. Transduction effic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Chae-Eun, Choi, Sewoon, Lee, Ju Hee, Kang, Eun Hye, Ahn, Hyo Min, Roh, Tai Suk, Yun, Chae-Ok, Lee, Won Jai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139745/ https://www.ncbi.nlm.nih.gov/pubmed/32213906 http://dx.doi.org/10.3390/ijms21062242

Ejemplares similares

Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling
por: Lee, Won Jai, et al.
Publicado: (2017)

Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
por: Yun, In Sik, et al.
Publicado: (2019)

A Novel sLRP6E1E2 Inhibits Canonical Wnt Signaling, Epithelial-to-Mesenchymal Transition, and Induces Mitochondria-Dependent Apoptosis in Lung Cancer
por: Lee, Jung-Sun, et al.
Publicado: (2012)

sLRP1ng Up Glucose: LRP1 Regulates Hepatic Insulin Responses
por: Lee, Stephen D., et al.
Publicado: (2016)

Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
por: Jung, Bok Ki, et al.
Publicado: (2017)

Effect of Mortalin on Scar Formation in Human Dermal Fibroblasts and a Rat Incisional Scar Model
por: Jung, Bok Ki, et al.
Publicado: (2022)

Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control
por: García, Eduardo, et al.
Publicado: (2023)

Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model
por: Jeong, Woonhyeok, et al.
Publicado: (2017)

Development of replication-competent adenovirus for bladder cancer by controlling adenovirus E1a and E4 gene expression with the survivin promoter
por: Seo, Ho Kyung, et al.
Publicado: (2014)

Evaluation the Surface Antigen of the Salmonella typhimurium ATCC 14028 Ghosts Prepared by “SLRP”
por: Amro, Amara A., et al.
Publicado: (2014)

Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish
por: Costa, R. A., et al.
Publicado: (2018)

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
por: Mysinger, Michael M., et al.
Publicado: (2012)

Gene Therapy Using Hepatocyte Growth Factor Expressing Adenovirus Improves Skin Flap Survival in a Rat Model
por: Rah, Dong Kyun, et al.
Publicado: (2014)

eHealth Literacy Instruments: Systematic Review of Measurement Properties
por: Lee, Jiyeon, et al.
Publicado: (2021)

Sulfated Glycosaminoglycans as Viral Decoy Receptors for Human Adenovirus Type 37
por: Chandra, Naresh, et al.
Publicado: (2019)

Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy
por: Ahn, Hyo Min, et al.
Publicado: (2016)

Novel LRP6 Mutations Causing Non-Syndromic Oligodontia
por: Lee, Yejin, et al.
Publicado: (2022)

High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-κB Signaling in Keloid Scar Formation
por: Kim, Jihee, et al.
Publicado: (2017)

Values of a Patient and Observer Scar Assessment Scale to Evaluate the Facial Skin Graft Scar
por: Chae, Jin Kyung, et al.
Publicado: (2016)

From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
por: Zappia, Jérémie, et al.
Publicado: (2020)

Imaging of Viral Thymidine Kinase Gene Expression by Replicating Oncolytic Adenovirus and Prediction of Therapeutic Efficacy
por: Kim, Eun-Jung, et al.
Publicado: (2008)

SNRPD2 Is a Novel Substrate for the Ubiquitin Ligase Activity of the Salmonella Type III Secretion Effector SlrP
por: Bullones-Bolaños, Andrea, et al.
Publicado: (2022)

Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus
por: Chandra, Naresh, et al.
Publicado: (2019)

Smad-binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts
por: Fan, Chen, et al.
Publicado: (2020)

Verapamil‐containing silicone gel reduces scar hypertrophy
por: Choi, Jangyoun, et al.
Publicado: (2021)

Zein-Induced Polyelectrolyte Complexes for Encapsulating Triterpenoid Phytochemicals
por: Kim, Yong-Jin, et al.
Publicado: (2023)

A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery
por: Thambi, Thavasyappan, et al.
Publicado: (2022)

Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains
por: Kim, Jinuk, et al.
Publicado: (2020)

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
por: Ren, Qian, et al.
Publicado: (2021)

Silicone Gel for Hypertrophic Scars
por: Wiwanitkit, Viroj
Publicado: (2010)

Inhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis
por: Lee, Dong Won, et al.
Publicado: (2020)

Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis
por: Jeon, Yeo Reum, et al.
Publicado: (2019)

Author Correction: Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains
por: Kim, Jinuk, et al.
Publicado: (2022)

No more helper adenovirus: production of gutless adenovirus (GLAd) free of adenovirus and replication-competent adenovirus (RCA) contaminants
por: Lee, Dongwoo, et al.
Publicado: (2019)

Placental expression of D6 decoy receptor in preeclampsia
por: Cho, Geum Joon, et al.
Publicado: (2015)

Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration
por: Yun, Kwan-Hee, et al.
Publicado: (2021)

Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6
por: MacDonald, Bryan T., et al.
Publicado: (2011)

Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues
por: Lee, Won Jai, et al.
Publicado: (2018)

Decoys provide a scalable platform for the identification of plant E3 ubiquitin ligases that regulate circadian function
por: Feke, Ann, et al.
Publicado: (2019)

DecoyFinder, a tool for finding decoy molecules
por: Adrià, Cereto Massagué, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_5qnnq3lgnugrfr8l7ekg7mk4a9