Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H(+), K(+)-ATPases in Pancreatic Cancer and Stellate Cells

Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma (PDAC) cells may utilize such transporters to acidify extracellular tumor microenvironment, creating a niche favoring cell proliferation, fibrosis and resistance to chemo...

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Detalles Bibliográficos
Autores principales: Tozzi, Marco, Sørensen, Christiane E., Magni, Lara, Christensen, Nynne M., Bouazzi, Rayhana, Buch, Caroline M., Stefanini, Matteo, Duranti, Claudia, Arcangeli, Annarosa, Novak, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139746/
https://www.ncbi.nlm.nih.gov/pubmed/32164284
http://dx.doi.org/10.3390/cancers12030640

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