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Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats

The aim of the present study is to investigate whether a disruption of the dipping pattern of blood pressure (BP) is associated with the progression of renal injury in Dahl salt-sensitive (DSS) hypertensive rats. Seven-week-old DSS rats were fed a high salt diet (HSD; 8% NaCl) for 10 weeks, followed...

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Autores principales: Sufiun, Abu, Rahman, Asadur, Rafiq, Kazi, Fujisawa, Yoshihide, Nakano, Daisuke, Kobara, Hideki, Masaki, Tsutomu, Nishiyama, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139748/
https://www.ncbi.nlm.nih.gov/pubmed/32213948
http://dx.doi.org/10.3390/ijms21062248
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author Sufiun, Abu
Rahman, Asadur
Rafiq, Kazi
Fujisawa, Yoshihide
Nakano, Daisuke
Kobara, Hideki
Masaki, Tsutomu
Nishiyama, Akira
author_facet Sufiun, Abu
Rahman, Asadur
Rafiq, Kazi
Fujisawa, Yoshihide
Nakano, Daisuke
Kobara, Hideki
Masaki, Tsutomu
Nishiyama, Akira
author_sort Sufiun, Abu
collection PubMed
description The aim of the present study is to investigate whether a disruption of the dipping pattern of blood pressure (BP) is associated with the progression of renal injury in Dahl salt-sensitive (DSS) hypertensive rats. Seven-week-old DSS rats were fed a high salt diet (HSD; 8% NaCl) for 10 weeks, followed by a transition to a normal salt diet (NSD; 0.3% NaCl) for 4 weeks. At baseline, NSD-fed DSS rats showed a dipper-type circadian rhythm of BP. By contrast, HSD for 5 days caused a significant increase in the difference between the active and inactive periods of BP with an extreme dipper type of BP, while proteinuria and renal tissue injury were not observed. Interestingly, HSD feeding for 10 weeks developed hypertension with a non-dipper pattern of BP, which was associated with obvious proteinuria and renal tissue injury. Four weeks after switching to an NSD, BP and proteinuria were significantly decreased, and the BP circadian rhythm returned to the normal dipper pattern. These data suggest that the non-dipper pattern of BP is associated with the progression of renal injury during the development of salt-dependent hypertension.
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spelling pubmed-71397482020-04-10 Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats Sufiun, Abu Rahman, Asadur Rafiq, Kazi Fujisawa, Yoshihide Nakano, Daisuke Kobara, Hideki Masaki, Tsutomu Nishiyama, Akira Int J Mol Sci Article The aim of the present study is to investigate whether a disruption of the dipping pattern of blood pressure (BP) is associated with the progression of renal injury in Dahl salt-sensitive (DSS) hypertensive rats. Seven-week-old DSS rats were fed a high salt diet (HSD; 8% NaCl) for 10 weeks, followed by a transition to a normal salt diet (NSD; 0.3% NaCl) for 4 weeks. At baseline, NSD-fed DSS rats showed a dipper-type circadian rhythm of BP. By contrast, HSD for 5 days caused a significant increase in the difference between the active and inactive periods of BP with an extreme dipper type of BP, while proteinuria and renal tissue injury were not observed. Interestingly, HSD feeding for 10 weeks developed hypertension with a non-dipper pattern of BP, which was associated with obvious proteinuria and renal tissue injury. Four weeks after switching to an NSD, BP and proteinuria were significantly decreased, and the BP circadian rhythm returned to the normal dipper pattern. These data suggest that the non-dipper pattern of BP is associated with the progression of renal injury during the development of salt-dependent hypertension. MDPI 2020-03-24 /pmc/articles/PMC7139748/ /pubmed/32213948 http://dx.doi.org/10.3390/ijms21062248 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sufiun, Abu
Rahman, Asadur
Rafiq, Kazi
Fujisawa, Yoshihide
Nakano, Daisuke
Kobara, Hideki
Masaki, Tsutomu
Nishiyama, Akira
Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats
title Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats
title_full Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats
title_fullStr Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats
title_full_unstemmed Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats
title_short Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats
title_sort association of a disrupted dipping pattern of blood pressure with progression of renal injury during the development of salt-dependent hypertension in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139748/
https://www.ncbi.nlm.nih.gov/pubmed/32213948
http://dx.doi.org/10.3390/ijms21062248
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