FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles

Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs,...

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Detalles Bibliográficos
Autores principales: Ricklefs, Franz L., Maire, Cecile L., Matschke, Jakob, Dührsen, Lasse, Sauvigny, Thomas, Holz, Mareike, Kolbe, Katharina, Peine, Sven, Herold-Mende, Christel, Carter, Bob, Chiocca, E. Antonio, Lawler, Sean E., Westphal, Manfred, Lamszus, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139767/
https://www.ncbi.nlm.nih.gov/pubmed/32178271
http://dx.doi.org/10.3390/ijms21061931
Descripción
Sumario:Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.

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