FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles

Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs,...

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Autores principales: Ricklefs, Franz L., Maire, Cecile L., Matschke, Jakob, Dührsen, Lasse, Sauvigny, Thomas, Holz, Mareike, Kolbe, Katharina, Peine, Sven, Herold-Mende, Christel, Carter, Bob, Chiocca, E. Antonio, Lawler, Sean E., Westphal, Manfred, Lamszus, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139767/
https://www.ncbi.nlm.nih.gov/pubmed/32178271
http://dx.doi.org/10.3390/ijms21061931
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author Ricklefs, Franz L.
Maire, Cecile L.
Matschke, Jakob
Dührsen, Lasse
Sauvigny, Thomas
Holz, Mareike
Kolbe, Katharina
Peine, Sven
Herold-Mende, Christel
Carter, Bob
Chiocca, E. Antonio
Lawler, Sean E.
Westphal, Manfred
Lamszus, Katrin
author_facet Ricklefs, Franz L.
Maire, Cecile L.
Matschke, Jakob
Dührsen, Lasse
Sauvigny, Thomas
Holz, Mareike
Kolbe, Katharina
Peine, Sven
Herold-Mende, Christel
Carter, Bob
Chiocca, E. Antonio
Lawler, Sean E.
Westphal, Manfred
Lamszus, Katrin
author_sort Ricklefs, Franz L.
collection PubMed
description Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
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spelling pubmed-71397672020-04-10 FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles Ricklefs, Franz L. Maire, Cecile L. Matschke, Jakob Dührsen, Lasse Sauvigny, Thomas Holz, Mareike Kolbe, Katharina Peine, Sven Herold-Mende, Christel Carter, Bob Chiocca, E. Antonio Lawler, Sean E. Westphal, Manfred Lamszus, Katrin Int J Mol Sci Article Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs. MDPI 2020-03-12 /pmc/articles/PMC7139767/ /pubmed/32178271 http://dx.doi.org/10.3390/ijms21061931 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ricklefs, Franz L.
Maire, Cecile L.
Matschke, Jakob
Dührsen, Lasse
Sauvigny, Thomas
Holz, Mareike
Kolbe, Katharina
Peine, Sven
Herold-Mende, Christel
Carter, Bob
Chiocca, E. Antonio
Lawler, Sean E.
Westphal, Manfred
Lamszus, Katrin
FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
title FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
title_full FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
title_fullStr FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
title_full_unstemmed FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
title_short FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
title_sort fasn is a biomarker enriched in malignant glioma-derived extracellular vesicles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139767/
https://www.ncbi.nlm.nih.gov/pubmed/32178271
http://dx.doi.org/10.3390/ijms21061931
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