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Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure

Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated...

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Autores principales: Wu, Meng-Yu, Chen, Chien-Sheng, Tsay, Chih-Yi, Yiang, Giou-Teng, Ke, Jian-Yu, Lin, Po-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139770/
https://www.ncbi.nlm.nih.gov/pubmed/32192003
http://dx.doi.org/10.3390/brainsci10030171
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author Wu, Meng-Yu
Chen, Chien-Sheng
Tsay, Chih-Yi
Yiang, Giou-Teng
Ke, Jian-Yu
Lin, Po-Chen
author_facet Wu, Meng-Yu
Chen, Chien-Sheng
Tsay, Chih-Yi
Yiang, Giou-Teng
Ke, Jian-Yu
Lin, Po-Chen
author_sort Wu, Meng-Yu
collection PubMed
description Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse–Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant Neisseria meningitidis-induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Fatal septicemia with DIC and multiple organ failure was noted. WFS was chiefly suspected. We highlight the clinical features and pathogenesis of Neisseria meningitidis-induced meningococcemia and WFS. We propose that they should be kept in mind, especially in patients presenting with a petechial eruption and purpura fulminans.
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spelling pubmed-71397702020-04-10 Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure Wu, Meng-Yu Chen, Chien-Sheng Tsay, Chih-Yi Yiang, Giou-Teng Ke, Jian-Yu Lin, Po-Chen Brain Sci Case Report Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse–Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant Neisseria meningitidis-induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Fatal septicemia with DIC and multiple organ failure was noted. WFS was chiefly suspected. We highlight the clinical features and pathogenesis of Neisseria meningitidis-induced meningococcemia and WFS. We propose that they should be kept in mind, especially in patients presenting with a petechial eruption and purpura fulminans. MDPI 2020-03-17 /pmc/articles/PMC7139770/ /pubmed/32192003 http://dx.doi.org/10.3390/brainsci10030171 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Wu, Meng-Yu
Chen, Chien-Sheng
Tsay, Chih-Yi
Yiang, Giou-Teng
Ke, Jian-Yu
Lin, Po-Chen
Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
title Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
title_full Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
title_fullStr Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
title_full_unstemmed Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
title_short Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure
title_sort neisseria meningitidis induced fatal waterhouse–friderichsen syndrome in a patient presenting with disseminated intravascular coagulation and multiple organ failure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139770/
https://www.ncbi.nlm.nih.gov/pubmed/32192003
http://dx.doi.org/10.3390/brainsci10030171
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