Cargando…

Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition

Background: Hepatocellular carcinoma (HCC) represents a major health burden with limited curative treatment options. There is a substantial unmet need to develop innovative approaches to impact the progression of advanced HCC. Haprolid is a novel natural component isolated from myxobacteria. Haproli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xing, Jun, Bhuria, Vikas, Bui, Khac Cuong, Nguyen, Mai Ly Thi, Hu, Zexi, Hsieh, Chih-Jen, Wittstein, Kathrin, Stadler, Marc, Wilkens, Ludwig, Li, Jun, Kalesse, Markus, Bozko, Przemyslaw, Plentz, Ruben R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139901/ https://www.ncbi.nlm.nih.gov/pubmed/32155915 http://dx.doi.org/10.3390/cancers12030615

Ejemplares similares

Gamma‐Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt‐Beta‐Catenin Pathways in CD44(+) Gastric Cancer Stem Cells
por: Barat, Samarpita, et al.
Publicado: (2017)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo
por: El Khatib, Mona, et al.
Publicado: (2013)

Correction: Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo
por: El Khatib, Mona, et al.
Publicado: (2018)

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells
por: Litchfield, Lacey M., et al.
Publicado: (2020)

Inhibition of mTor induces a paused pluripotent state
por: Bulut-Karslioglu, Aydan, et al.
Publicado: (2016)

Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation
por: Go, Ga-Yeon, et al.
Publicado: (2020)

Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model
por: Sun, Zhi-Jun, et al.
Publicado: (2013)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
por: Umanah, George K. E., et al.
Publicado: (2022)

mTOR inhibition in management of advanced breast cancer
por: Nag, Shona
Publicado: (2012)

Everolimus and mTOR inhibition in pancreatic neuroendocrine tumors
por: Yim, Kein-Leong
Publicado: (2012)

mTOR Inhibition: From Aging to Autism and Beyond
por: Kaeberlein, Matt
Publicado: (2013)

Exploring mTOR inhibition as treatment for mitochondrial disease
por: Sage‐Schwaede, Abigail, et al.
Publicado: (2019)

mTOR inhibition impairs extinction memory reconsolidation
por: Radiske, Andressa, et al.
Publicado: (2021)

FUS contributes to mTOR-dependent inhibition of translation
por: Sévigny, Myriam, et al.
Publicado: (2021)

Brain-restricted mTOR inhibition with binary pharmacology
por: Zhang, Ziyang, et al.
Publicado: (2022)

Medical Aspects of mTOR Inhibition in Kidney Transplantation
por: Cuadrado-Payán, Elena, et al.
Publicado: (2022)

Epithelial Mesenchymal Transition and Pancreatic Tumor Initiating CD44+/EpCAM+ Cells Are Inhibited by γ-Secretase Inhibitor IX
por: Palagani, Vindhya, et al.
Publicado: (2012)

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
por: Lyu, Junfang, et al.
Publicado: (2018)

Dual Inhibition of CDK4/Rb and PI3K/AKT/mTOR Pathways by ON123300 Induces Synthetic Lethality in Mantle Cell Lymphomas
por: Divakar, Saikrishna A., et al.
Publicado: (2015)

Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells
por: Li, Yue, et al.
Publicado: (2017)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies
por: Lyu, Jing-Wei, et al.
Publicado: (2019)

PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling
por: Ma, Ning, et al.
Publicado: (2021)

mTOR inhibition as a novel gene therapeutic strategy for diabetic retinopathy
por: Lee, Steven Hyun Seung, et al.
Publicado: (2022)

Pml represses tumour progression through inhibition of mTOR
por: Bernardi, Rosa, et al.
Publicado: (2011)

mTOR Inhibition: A Promise for a Young Heart
por: Cau, Stefany B. A., et al.
Publicado: (2012)

Is mTOR inhibition a systemic treatment for tuberous sclerosis?
por: Moavero, Romina, et al.
Publicado: (2013)

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
por: Walters, Hannah E., et al.
Publicado: (2016)

mTOR inhibition rescues osteopenia in mice with systemic sclerosis
por: Chen, Chider, et al.
Publicado: (2015)

Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia
por: Guo, Naxin, et al.
Publicado: (2019)

Inhaled biguanides and mTOR inhibition for influenza and coronavirus (Review)
por: LEHRER, STEVEN
Publicado: (2020)

Tissue-restricted inhibition of mTOR using chemical genetics
por: Wassarman, Douglas R., et al.
Publicado: (2022)

Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice
por: Ueda, Yo, et al.
Publicado: (2019)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
por: Spormann, Luise, et al.
Publicado: (2020)

Ginsenoside Rb3 provides protective effects against cisplatin‐induced nephrotoxicity via regulation of AMPK‐/mTOR‐mediated autophagy and inhibition of apoptosis in vitro and in vivo
por: Xing, Jing‐jing, et al.
Publicado: (2019)

Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition
por: Yang, Aimin, et al.
Publicado: (2015)

Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head
por: Liao, Yun, et al.
Publicado: (2017)

HIF is not essential for suppression of experimental tumor growth by mTOR inhibition
por: Knaup, Karl X., et al.
Publicado: (2017)

Regulation of Autophagy in Chick Skeletal Muscle: Effect of mTOR Inhibition
por: Nakashima, Kazuki, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r1ntmjb1k94jminflhjpffcgee