The Bradykinin-BDKRB1 Axis Regulates Aquaporin 4 Gene Expression and Consequential Migration and Invasion of Malignant Glioblastoma Cells via a Ca(2+)-MEK1-ERK1/2-NF-κB Mechanism

Glioblastoma multiforme (GBM) is the most common form of brain tumor and is very aggressive. Rapid migration and invasion of glioblastoma cells are two typical features driving malignance of GBM. Bradykinin functionally prompts calcium influx via activation of bradykinin receptor B1/B2 (BDKRB1/2). I...

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Detalles Bibliográficos
Autores principales: Sun, Ding-Ping, Lee, Yuan-Wen, Chen, Jui-Tai, Lin, Yung-Wei, Chen, Ruei-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139930/
https://www.ncbi.nlm.nih.gov/pubmed/32182968
http://dx.doi.org/10.3390/cancers12030667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139930/
https://www.ncbi.nlm.nih.gov/pubmed/32182968
http://dx.doi.org/10.3390/cancers12030667

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