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Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle
Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid dro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139950/ https://www.ncbi.nlm.nih.gov/pubmed/32178449 http://dx.doi.org/10.3390/ijms21061949 |
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author | Park, Sung Sup Seo, Young-Kyo |
author_facet | Park, Sung Sup Seo, Young-Kyo |
author_sort | Park, Sung Sup |
collection | PubMed |
description | Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid droplets leads to intramuscular accumulation of lipid intermediates. The resulting downregulation of the insulin signaling cascade prevents the translocation of glucose transporter to the plasma membrane and glucose uptake into skeletal muscle, leading to metabolic disorders such as type 2 diabetes. The mechanisms underlining metabolic dysfunction in skeletal muscle include accumulation of intracellular lipid derivatives from elevated plasma FFAs. This paper provides a review of the molecular mechanisms underlying insulin-related signaling pathways after excess accumulation of lipids. |
format | Online Article Text |
id | pubmed-7139950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71399502020-04-13 Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle Park, Sung Sup Seo, Young-Kyo Int J Mol Sci Review Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid droplets leads to intramuscular accumulation of lipid intermediates. The resulting downregulation of the insulin signaling cascade prevents the translocation of glucose transporter to the plasma membrane and glucose uptake into skeletal muscle, leading to metabolic disorders such as type 2 diabetes. The mechanisms underlining metabolic dysfunction in skeletal muscle include accumulation of intracellular lipid derivatives from elevated plasma FFAs. This paper provides a review of the molecular mechanisms underlying insulin-related signaling pathways after excess accumulation of lipids. MDPI 2020-03-12 /pmc/articles/PMC7139950/ /pubmed/32178449 http://dx.doi.org/10.3390/ijms21061949 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Sung Sup Seo, Young-Kyo Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle |
title | Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle |
title_full | Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle |
title_fullStr | Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle |
title_full_unstemmed | Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle |
title_short | Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle |
title_sort | excess accumulation of lipid impairs insulin sensitivity in skeletal muscle |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139950/ https://www.ncbi.nlm.nih.gov/pubmed/32178449 http://dx.doi.org/10.3390/ijms21061949 |
work_keys_str_mv | AT parksungsup excessaccumulationoflipidimpairsinsulinsensitivityinskeletalmuscle AT seoyoungkyo excessaccumulationoflipidimpairsinsulinsensitivityinskeletalmuscle |