Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview...

Descripción completa

Detalles Bibliográficos
Autores principales: Colpitts, Che C., Tsai, Pei-Ling, Zeisel, Mirjam B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140000/
https://www.ncbi.nlm.nih.gov/pubmed/32197477
http://dx.doi.org/10.3390/ijms21062091
_version_ 1783518896224993280
author Colpitts, Che C.
Tsai, Pei-Ling
Zeisel, Mirjam B.
author_facet Colpitts, Che C.
Tsai, Pei-Ling
Zeisel, Mirjam B.
author_sort Colpitts, Che C.
collection PubMed
description Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.
format Online
Article
Text
id pubmed-7140000
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71400002020-04-13 Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process Colpitts, Che C. Tsai, Pei-Ling Zeisel, Mirjam B. Int J Mol Sci Review Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors. MDPI 2020-03-18 /pmc/articles/PMC7140000/ /pubmed/32197477 http://dx.doi.org/10.3390/ijms21062091 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colpitts, Che C.
Tsai, Pei-Ling
Zeisel, Mirjam B.
Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_full Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_fullStr Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_full_unstemmed Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_short Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_sort hepatitis c virus entry: an intriguingly complex and highly regulated process
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140000/
https://www.ncbi.nlm.nih.gov/pubmed/32197477
http://dx.doi.org/10.3390/ijms21062091
work_keys_str_mv AT colpittschec hepatitiscvirusentryanintriguinglycomplexandhighlyregulatedprocess
AT tsaipeiling hepatitiscvirusentryanintriguinglycomplexandhighlyregulatedprocess
AT zeiselmirjamb hepatitiscvirusentryanintriguinglycomplexandhighlyregulatedprocess

Ejemplares similares