Cargando…
The Regulatory Functions of Circular RNAs in Digestive System Cancers
Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated ci...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140005/ https://www.ncbi.nlm.nih.gov/pubmed/32213977 http://dx.doi.org/10.3390/cancers12030770 |
_version_ | 1783518897432952832 |
---|---|
author | Yuan, Xiao Yuan, Ya He, Zhi Li, Diyan Zeng, Bo Ni, Qingyong Yang, Mingyao Yang, Deying |
author_facet | Yuan, Xiao Yuan, Ya He, Zhi Li, Diyan Zeng, Bo Ni, Qingyong Yang, Mingyao Yang, Deying |
author_sort | Yuan, Xiao |
collection | PubMed |
description | Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer. |
format | Online Article Text |
id | pubmed-7140005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71400052020-04-13 The Regulatory Functions of Circular RNAs in Digestive System Cancers Yuan, Xiao Yuan, Ya He, Zhi Li, Diyan Zeng, Bo Ni, Qingyong Yang, Mingyao Yang, Deying Cancers (Basel) Review Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer. MDPI 2020-03-24 /pmc/articles/PMC7140005/ /pubmed/32213977 http://dx.doi.org/10.3390/cancers12030770 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yuan, Xiao Yuan, Ya He, Zhi Li, Diyan Zeng, Bo Ni, Qingyong Yang, Mingyao Yang, Deying The Regulatory Functions of Circular RNAs in Digestive System Cancers |
title | The Regulatory Functions of Circular RNAs in Digestive System Cancers |
title_full | The Regulatory Functions of Circular RNAs in Digestive System Cancers |
title_fullStr | The Regulatory Functions of Circular RNAs in Digestive System Cancers |
title_full_unstemmed | The Regulatory Functions of Circular RNAs in Digestive System Cancers |
title_short | The Regulatory Functions of Circular RNAs in Digestive System Cancers |
title_sort | regulatory functions of circular rnas in digestive system cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140005/ https://www.ncbi.nlm.nih.gov/pubmed/32213977 http://dx.doi.org/10.3390/cancers12030770 |
work_keys_str_mv | AT yuanxiao theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT yuanya theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT hezhi theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT lidiyan theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT zengbo theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT niqingyong theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT yangmingyao theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT yangdeying theregulatoryfunctionsofcircularrnasindigestivesystemcancers AT yuanxiao regulatoryfunctionsofcircularrnasindigestivesystemcancers AT yuanya regulatoryfunctionsofcircularrnasindigestivesystemcancers AT hezhi regulatoryfunctionsofcircularrnasindigestivesystemcancers AT lidiyan regulatoryfunctionsofcircularrnasindigestivesystemcancers AT zengbo regulatoryfunctionsofcircularrnasindigestivesystemcancers AT niqingyong regulatoryfunctionsofcircularrnasindigestivesystemcancers AT yangmingyao regulatoryfunctionsofcircularrnasindigestivesystemcancers AT yangdeying regulatoryfunctionsofcircularrnasindigestivesystemcancers |