Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

Human RNASET2 acts as a powerful oncosuppressor protein in in vivo xenograft-based murine models of human cancer. Secretion of RNASET2 in the tumor microenvironment seems involved in tumor suppression, following recruitment of M1-polarized macrophages. Here, we report a murine Rnaset2-based syngenei...

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Detalles Bibliográficos
Autores principales: De Vito, Annarosaria, Orecchia, Paola, Balza, Enrica, Reverberi, Daniele, Scaldaferri, Debora, Taramelli, Roberto, Noonan, Douglas M., Acquati, Francesco, Mortara, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140044/
https://www.ncbi.nlm.nih.gov/pubmed/32197460
http://dx.doi.org/10.3390/cancers12030717

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