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A Model of a Zebrafish Avatar for Co-Clinical Trials

Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the cancer cells of the patient’s tumor are xenotransplanted into the animal avatar for drug efficacy studies, and the data collected in the animal trial are use...

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Detalles Bibliográficos
Autores principales: Usai, Alice, Di Franco, Gregorio, Colucci, Patrizia, Pollina, Luca Emanuele, Vasile, Enrico, Funel, Niccola, Palmeri, Matteo, Dente, Luciana, Falcone, Alfredo, Morelli, Luca, Raffa, Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140063/
https://www.ncbi.nlm.nih.gov/pubmed/32183229
http://dx.doi.org/10.3390/cancers12030677
Descripción
Sumario:Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the cancer cells of the patient’s tumor are xenotransplanted into the animal avatar for drug efficacy studies, and the data collected in the animal trial are used to plan the best drug treatment in the patient trial. Zebrafish have recently been proposed for implementing avatar models, however the lack of a general criterion for the chemotherapy dose conversion from humans to fish is a limitation in terms of conducting co-clinical trials. Here, we validate a simple, reliant and cost-effective avatar model based on the use of zebrafish embryos. By crossing data from safety and efficacy studies, we found a basic formula for estimating the equivalent dose for use in co-clinical trials which we validated in a clinical study enrolling 24 adult patients with solid cancers (XenoZ, NCT03668418).