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A Model of a Zebrafish Avatar for Co-Clinical Trials

Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the cancer cells of the patient’s tumor are xenotransplanted into the animal avatar for drug efficacy studies, and the data collected in the animal trial are use...

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Autores principales: Usai, Alice, Di Franco, Gregorio, Colucci, Patrizia, Pollina, Luca Emanuele, Vasile, Enrico, Funel, Niccola, Palmeri, Matteo, Dente, Luciana, Falcone, Alfredo, Morelli, Luca, Raffa, Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140063/
https://www.ncbi.nlm.nih.gov/pubmed/32183229
http://dx.doi.org/10.3390/cancers12030677
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author Usai, Alice
Di Franco, Gregorio
Colucci, Patrizia
Pollina, Luca Emanuele
Vasile, Enrico
Funel, Niccola
Palmeri, Matteo
Dente, Luciana
Falcone, Alfredo
Morelli, Luca
Raffa, Vittoria
author_facet Usai, Alice
Di Franco, Gregorio
Colucci, Patrizia
Pollina, Luca Emanuele
Vasile, Enrico
Funel, Niccola
Palmeri, Matteo
Dente, Luciana
Falcone, Alfredo
Morelli, Luca
Raffa, Vittoria
author_sort Usai, Alice
collection PubMed
description Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the cancer cells of the patient’s tumor are xenotransplanted into the animal avatar for drug efficacy studies, and the data collected in the animal trial are used to plan the best drug treatment in the patient trial. Zebrafish have recently been proposed for implementing avatar models, however the lack of a general criterion for the chemotherapy dose conversion from humans to fish is a limitation in terms of conducting co-clinical trials. Here, we validate a simple, reliant and cost-effective avatar model based on the use of zebrafish embryos. By crossing data from safety and efficacy studies, we found a basic formula for estimating the equivalent dose for use in co-clinical trials which we validated in a clinical study enrolling 24 adult patients with solid cancers (XenoZ, NCT03668418).
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spelling pubmed-71400632020-04-13 A Model of a Zebrafish Avatar for Co-Clinical Trials Usai, Alice Di Franco, Gregorio Colucci, Patrizia Pollina, Luca Emanuele Vasile, Enrico Funel, Niccola Palmeri, Matteo Dente, Luciana Falcone, Alfredo Morelli, Luca Raffa, Vittoria Cancers (Basel) Article Animal “avatars” and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the cancer cells of the patient’s tumor are xenotransplanted into the animal avatar for drug efficacy studies, and the data collected in the animal trial are used to plan the best drug treatment in the patient trial. Zebrafish have recently been proposed for implementing avatar models, however the lack of a general criterion for the chemotherapy dose conversion from humans to fish is a limitation in terms of conducting co-clinical trials. Here, we validate a simple, reliant and cost-effective avatar model based on the use of zebrafish embryos. By crossing data from safety and efficacy studies, we found a basic formula for estimating the equivalent dose for use in co-clinical trials which we validated in a clinical study enrolling 24 adult patients with solid cancers (XenoZ, NCT03668418). MDPI 2020-03-13 /pmc/articles/PMC7140063/ /pubmed/32183229 http://dx.doi.org/10.3390/cancers12030677 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Usai, Alice
Di Franco, Gregorio
Colucci, Patrizia
Pollina, Luca Emanuele
Vasile, Enrico
Funel, Niccola
Palmeri, Matteo
Dente, Luciana
Falcone, Alfredo
Morelli, Luca
Raffa, Vittoria
A Model of a Zebrafish Avatar for Co-Clinical Trials
title A Model of a Zebrafish Avatar for Co-Clinical Trials
title_full A Model of a Zebrafish Avatar for Co-Clinical Trials
title_fullStr A Model of a Zebrafish Avatar for Co-Clinical Trials
title_full_unstemmed A Model of a Zebrafish Avatar for Co-Clinical Trials
title_short A Model of a Zebrafish Avatar for Co-Clinical Trials
title_sort model of a zebrafish avatar for co-clinical trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140063/
https://www.ncbi.nlm.nih.gov/pubmed/32183229
http://dx.doi.org/10.3390/cancers12030677
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