Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts

TP53, the most commonly-mutated gene in cancer, undergoes complex alternative splicing. Different TP53 transcripts play different biological roles, both in normal function and in the progression of diseases such as cancer. The study of TP53’s alternative RNA splice forms and their use as clinical bi...

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Detalles Bibliográficos
Autores principales: Lasham, Annette, Tsai, Peter, Fitzgerald, Sandra J., Mehta, Sunali Y., Knowlton, Nicholas S., Braithwaite, Antony W., Print, Cristin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140069/
https://www.ncbi.nlm.nih.gov/pubmed/32213968
http://dx.doi.org/10.3390/cancers12030769

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