Cargando…

STAT3 Mutation Is Associated with STAT3 Activation in CD30(+) ALK(−) ALCL

Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the various subtypes, and the JAK/STAT pathway has been fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andersson, Emma I., Brück, Oscar, Braun, Till, Mannisto, Susanna, Saikko, Leena, Lagström, Sonja, Ellonen, Pekka, Leppä, Sirpa, Herling, Marco, Kovanen, Panu E., Mustjoki, Satu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140109/ https://www.ncbi.nlm.nih.gov/pubmed/32188095 http://dx.doi.org/10.3390/cancers12030702

Ejemplares similares

Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia
por: Savola, Paula, et al.
Publicado: (2018)

Phosphorylated STAT3 as a potential diagnostic and predictive biomarker in ALK(-) ALCL vs. CD30(high) PTCL, NOS
por: Xiang, Chenxi, et al.
Publicado: (2023)

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
por: Dufva, Olli, et al.
Publicado: (2018)

The heterogeneous landscape of ALK negative ALCL
por: Mereu, Elisabetta, et al.
Publicado: (2017)

T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma
por: Leivonen, Suvi-Katri, et al.
Publicado: (2019)

PD-L1(+) tumor-associated macrophages and PD-1(+) tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma
por: Pollari, Marjukka, et al.
Publicado: (2018)

Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma
por: Karihtala, Kristiina, et al.
Publicado: (2020)

STAT5b in LGL leukemia – a novel therapeutic target?
por: Rajala, Hanna L. M., et al.
Publicado: (2013)

Direct Targeting Options for STAT3 and STAT5 in Cancer
por: Orlova, Anna, et al.
Publicado: (2019)

JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL
por: Wahnschaffe, Linus, et al.
Publicado: (2019)

ALK+ ALCL in the setting of adalimumab‐related hidradenitis suppurativa
por: Craig, Alexander, et al.
Publicado: (2023)

JAK‐STAT core cancer pathway: An integrative cancer interactome analysis
por: Erdogan, Fettah, et al.
Publicado: (2022)

The ALK inhibitors, alectinib and ceritinib, induce ALK‐independent and STAT3‐dependent glioblastoma cell death
por: Kawauchi, Daisuke, et al.
Publicado: (2021)

Erythroid Progenitor Cells Expanded from Peripheral Blood without Mobilization or Preselection: Molecular Characteristics and Functional Competence
por: Filippone, Claudia, et al.
Publicado: (2010)

Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL
por: Hohtari, Helena, et al.
Publicado: (2019)

STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation
por: Kim, Daehong, et al.
Publicado: (2021)

Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL
por: Hare, Lucy, et al.
Publicado: (2021)

P1235: INVESTIGATION OF THE CO-MUTATIONAL LANDSCAPE OF ALK-POSITIVE ALCL
por: Villa, Matteo, et al.
Publicado: (2023)

SBNO2 is a critical mediator of STAT3-driven hematological malignancies
por: Brandstoetter, Tania, et al.
Publicado: (2023)

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation
por: Andersson, E I, et al.
Publicado: (2013)

High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls
por: Valori, Miko, et al.
Publicado: (2022)

Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma
por: Autio, Matias, et al.
Publicado: (2020)

Somatic STAT3 mutations in CD8(+) T cells of healthy blood donors carrying human T-cell leukemia virus type 2
por: Kim, Daehong, et al.
Publicado: (2021)

PB2372: PP2A INHIBITOR LB100 ENHANCES THE SENSITIVITY OF NPM-ALK+ALCL TO CRIZOTINIB AND REVERSES THE RESISTANCE OF ALCL TO CRIZOTINIB
por: Shi, Wenyu
Publicado: (2023)

ALK+ Anaplastic Large Cell Lymphoma (ALCL)-Derived Exosomes Carry ALK Signaling Proteins and Interact with Tumor Microenvironment
por: Chioureas, Dimitrios, et al.
Publicado: (2022)

Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients
por: Brück, Oscar, et al.
Publicado: (2021)

Targeting STAT3 and STAT5 in Cancer
por: de Araujo, Elvin D., et al.
Publicado: (2020)

Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs
por: Pearson, Joel D, et al.
Publicado: (2014)

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling
por: Kuusanmäki, Heikki, et al.
Publicado: (2017)

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
por: Hua, Yaping, et al.
Publicado: (2022)

Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3
por: Yu, Xiaokui, et al.
Publicado: (2015)

Somatic mutations and T-cell clonality in patients with immunodeficiency
por: Savola, Paula, et al.
Publicado: (2019)

STAT3 but Not STAT1 Is Required for Astrocyte Differentiation
por: Hong, Seulgi, et al.
Publicado: (2014)

Redox Regulation of STAT1 and STAT3 Signaling
por: Butturini, Elena, et al.
Publicado: (2020)

STAT3 and STAT5 Activation in Solid Cancers
por: Igelmann, Sebastian, et al.
Publicado: (2019)

Expression of JAK3, STAT2, STAT4, and STAT6 in pemphigus vulgaris
por: Juczynska, K., et al.
Publicado: (2020)

Erratum to: ‘Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs’
por: Pearson, Jodel D., et al.
Publicado: (2016)

Revealing the true face behind the mask of ALK-positive anaplastic large cell lymphoma (ALCL)
por: Eisfeld, Hannah, et al.
Publicado: (2020)

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
por: Kollmann, Sebastian, et al.
Publicado: (2019)

Primary Cutaneous CD30+/ALK- ALCL with Transition into sALCL: Favourable Response after Systemic Administration with Brentuximab Vedotin! Unique Presentation in a Bulgarian Patient!
por: Popova, Tanya Naskova, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_eng0umc1bhbvdhpr9ib7gfc329