Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety

Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in the development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using cleavable linkers, and this design concept still has insurmountable drawbacks. Their potential instabilities...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yanming, Liu, Lianqi, Fan, Shiyong, Xiao, Dian, Xie, Fei, Li, Wei, Zhong, Wu, Zhou, Xinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140114/
https://www.ncbi.nlm.nih.gov/pubmed/32245171
http://dx.doi.org/10.3390/cancers12030744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140114/
https://www.ncbi.nlm.nih.gov/pubmed/32245171
http://dx.doi.org/10.3390/cancers12030744

Ejemplares similares