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Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety

Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in the development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using cleavable linkers, and this design concept still has insurmountable drawbacks. Their potential instabilities...

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Detalles Bibliográficos
Autores principales:	Wang, Yanming, Liu, Lianqi, Fan, Shiyong, Xiao, Dian, Xie, Fei, Li, Wei, Zhong, Wu, Zhou, Xinbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140114/ https://www.ncbi.nlm.nih.gov/pubmed/32245171 http://dx.doi.org/10.3390/cancers12030744

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