Cargando…

Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

BACKGROUND: TSC1-related signaling plays a pivotal role in intramembranous and endochondral ossification processes during skeletogenesis. This study was aimed at determining the significance of the TSC1 gene at different stages of spinal development. Materials and Methods. TSC1-floxed mice (TSC1(flo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Cheng, Liao, Jianwen, Lai, Pinglin, Huang, Hai, Fan, Shicai, Chen, Yuhui, Bai, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140121/ https://www.ncbi.nlm.nih.gov/pubmed/32309432 http://dx.doi.org/10.1155/2020/4572687

Ejemplares similares

Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice
por: Yang, Cheng, et al.
Publicado: (2017)

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway
por: Huang, Bin, et al.
Publicado: (2015)

A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development
por: Jones, Iwan, et al.
Publicado: (2015)

Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
por: Li, Yi, et al.
Publicado: (2018)

Effect of Quercetin on Preosteoblasts and Bone Defects
por: Wong, R.W.K, et al.
Publicado: (2008)

Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
por: Lin, Chuangxin, et al.
Publicado: (2019)

New PCL/PEC Blends: In Vitro Cell Response of Preosteoblasts and Human Mesenchymal Stem Cells
por: Pablos, Jesus L., et al.
Publicado: (2022)

Correction to: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
por: Lin, Chuangxin, et al.
Publicado: (2019)

Osteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge
por: Kuo, Zong-Keng, et al.
Publicado: (2016)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Molecular rescue of Tsc1-ablated cortical tuber mice
por: Robens, Barbara, et al.
Publicado: (2016)

Investigation of the changes of biophysical/mechanical characteristics of differentiating preosteoblasts in vitro
por: Subbiah, Ramesh, et al.
Publicado: (2015)

NADPH Oxidase Isoforms Are Involved in Glucocorticoid-Induced Preosteoblast Apoptosis
por: Bai, Shu-Cai, et al.
Publicado: (2019)

Effect of surface grain boundary density on preosteoblast proliferation on titanium
por: Lowe, Terry C., et al.
Publicado: (2020)

In Vitro Non-Genomic Effects of Calcifediol on Human Preosteoblastic Cells
por: Donati, Simone, et al.
Publicado: (2021)

Different Sex-Based Responses of Gut Microbiota During the Development of Hepatocellular Carcinoma in Liver-Specific Tsc1-Knockout Mice
por: Huang, Rong, et al.
Publicado: (2018)

Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2(−)/(−) Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM
por: Lesma, Elena, et al.
Publicado: (2008)

Erratum to: Investigation of the changes of biophysical/mechanical characteristics of differentiating preosteoblasts in vitro
por: Subbiah, Ramesh, et al.
Publicado: (2016)

mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts
por: Chen, Jianquan, et al.
Publicado: (2015)

Telomerase Allows Human Preosteoblasts to Maintain Their Phenotype during the Immortalization Process
por: Darimont, Christian, et al.
Publicado: (2001)

Inhibitory Effects of Alendronate on Adhesion and Viability of Preosteoblast Cells on Titanium Discs
por: Lilakhunakon, Charukrit, et al.
Publicado: (2021)

Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila
por: Nagy, Péter, et al.
Publicado: (2016)

Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion
por: Zahedi, Kamyar, et al.
Publicado: (2022)

Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice
por: Dai, Yuxing, et al.
Publicado: (2023)

Tuberculosis and Slight Ailments
Publicado: (1899)

A Slight Misunderstanding
Publicado: (1896)

Treatment of Slight Wounds
Publicado: (1891)

A Slight Mistake
Publicado: (1894)

Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells
por: Boutin, Alisa, et al.
Publicado: (2016)

Chondrocyte-Specific Inhibition of β-Catenin Signaling Leads to Dysplasia of the Caudal Vertebrae in Mice
por: Shu, Bing, et al.
Publicado: (2013)

Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia
por: Gourgas, Ophélie, et al.
Publicado: (2023)

Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse
por: Wu, Zhixiang, et al.
Publicado: (2019)

mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a
por: Chen, Ajuan, et al.
Publicado: (2022)

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
por: Tyburczy, Magdalena E., et al.
Publicado: (2015)

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2
por: Kwiatkowski, David J, et al.
Publicado: (2015)

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)
por: Fuso, A., et al.
Publicado: (2016)

Evidence for population variation in TSC1 and TSC2 gene expression
por: Jentarra, Garilyn M, et al.
Publicado: (2011)

The preosteoblast response of electrospinning PLGA/PCL nanofibers: effects of biomimetic architecture and collagen I
por: Qian, Yunzhu, et al.
Publicado: (2016)

Biological Effects of Polyrotaxane Surfaces on Cellular Responses of Fibroblast, Preosteoblast and Preadipocyte Cell Lines
por: Masuda, Hiroki, et al.
Publicado: (2020)

Report of a Slight Outbreak of Epidemic Cerebro-Spinal Meningitis, with Notes of Six Cases
por: Frew, William
Publicado: (1884)

Cannot write session to /tmp/vufind_sessions/sess_t3bd5tt623b1uila54pob26kds