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Atherosclerotic Risk Factors in Children with Celiac Disease

RESULTS: We found significantly lower concentrations of total cholesterol, lipoprotein LDL-C, apolipoproteins A1 and B, as well as hCRP in all children with CD. We showed decreased level (<5 ng/mL) of folic acid among 46% of children treated for >5 years. Moreover, we showed significant decrea...

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Autores principales: Rybak, Anna, Wierzbicka, Aldona, Socha, Piotr, Stolarczyk, Anna, Cukrowska, Bożena, Obrycki, Łukasz, Wawer, Zbigniew, Janas, Roman, Oralewska, Beata, Szaflarska-Popławska, Anna, Iwańczak, Barbara, Cyrta-Jarocka, Elżbieta, Grzybowska-Chlebowczyk, Urszula, Cichy, Wojciech, Czaja-Bulsa, Grażyna, Socha, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140124/
https://www.ncbi.nlm.nih.gov/pubmed/32308675
http://dx.doi.org/10.1155/2020/6138243
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author Rybak, Anna
Wierzbicka, Aldona
Socha, Piotr
Stolarczyk, Anna
Cukrowska, Bożena
Obrycki, Łukasz
Wawer, Zbigniew
Janas, Roman
Oralewska, Beata
Szaflarska-Popławska, Anna
Iwańczak, Barbara
Cyrta-Jarocka, Elżbieta
Grzybowska-Chlebowczyk, Urszula
Cichy, Wojciech
Czaja-Bulsa, Grażyna
Socha, Jerzy
author_facet Rybak, Anna
Wierzbicka, Aldona
Socha, Piotr
Stolarczyk, Anna
Cukrowska, Bożena
Obrycki, Łukasz
Wawer, Zbigniew
Janas, Roman
Oralewska, Beata
Szaflarska-Popławska, Anna
Iwańczak, Barbara
Cyrta-Jarocka, Elżbieta
Grzybowska-Chlebowczyk, Urszula
Cichy, Wojciech
Czaja-Bulsa, Grażyna
Socha, Jerzy
author_sort Rybak, Anna
collection PubMed
description RESULTS: We found significantly lower concentrations of total cholesterol, lipoprotein LDL-C, apolipoproteins A1 and B, as well as hCRP in all children with CD. We showed decreased level (<5 ng/mL) of folic acid among 46% of children treated for >5 years. Moreover, we showed significant decrease of folic acid level already after 1 year of a GFD (12 vs. 5.6 ng/mL; p < 0.001). We also found significant negative correlation of z-score body mass index (BMI) with HDL and APOA1 level (r = −0.33; p = 0.015 and r = −0.28; p = 0.038, respectively) and modest positive correlation of z-score BMI with atherogenic factor of total cholesterol-HDL ratio and LDL-HDL ratio (r = 0.40; p = 0.002 and r = 0.36; p = 0.006, respectively). Analysis of physical activity showed an increase in the insulin levels with inactivity (r = 0.36; p = 0.0025). We also found positive correlation of the sleep duration with the adiponectin level (r = 0.41; p = 0.011). CONCLUSIONS: In children with CD treated with a GFD, decreased level of folic acid together with increased BMI, sedentary behavior, and an improper lipid profile may predispose them to atherosclerosis in the long run. This data suggests the need of further studies to determine the need for metabolic cardiovascular risk screening in children with CD.
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spelling pubmed-71401242020-04-17 Atherosclerotic Risk Factors in Children with Celiac Disease Rybak, Anna Wierzbicka, Aldona Socha, Piotr Stolarczyk, Anna Cukrowska, Bożena Obrycki, Łukasz Wawer, Zbigniew Janas, Roman Oralewska, Beata Szaflarska-Popławska, Anna Iwańczak, Barbara Cyrta-Jarocka, Elżbieta Grzybowska-Chlebowczyk, Urszula Cichy, Wojciech Czaja-Bulsa, Grażyna Socha, Jerzy Gastroenterol Res Pract Research Article RESULTS: We found significantly lower concentrations of total cholesterol, lipoprotein LDL-C, apolipoproteins A1 and B, as well as hCRP in all children with CD. We showed decreased level (<5 ng/mL) of folic acid among 46% of children treated for >5 years. Moreover, we showed significant decrease of folic acid level already after 1 year of a GFD (12 vs. 5.6 ng/mL; p < 0.001). We also found significant negative correlation of z-score body mass index (BMI) with HDL and APOA1 level (r = −0.33; p = 0.015 and r = −0.28; p = 0.038, respectively) and modest positive correlation of z-score BMI with atherogenic factor of total cholesterol-HDL ratio and LDL-HDL ratio (r = 0.40; p = 0.002 and r = 0.36; p = 0.006, respectively). Analysis of physical activity showed an increase in the insulin levels with inactivity (r = 0.36; p = 0.0025). We also found positive correlation of the sleep duration with the adiponectin level (r = 0.41; p = 0.011). CONCLUSIONS: In children with CD treated with a GFD, decreased level of folic acid together with increased BMI, sedentary behavior, and an improper lipid profile may predispose them to atherosclerosis in the long run. This data suggests the need of further studies to determine the need for metabolic cardiovascular risk screening in children with CD. Hindawi 2020-03-27 /pmc/articles/PMC7140124/ /pubmed/32308675 http://dx.doi.org/10.1155/2020/6138243 Text en Copyright © 2020 Anna Rybak et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rybak, Anna
Wierzbicka, Aldona
Socha, Piotr
Stolarczyk, Anna
Cukrowska, Bożena
Obrycki, Łukasz
Wawer, Zbigniew
Janas, Roman
Oralewska, Beata
Szaflarska-Popławska, Anna
Iwańczak, Barbara
Cyrta-Jarocka, Elżbieta
Grzybowska-Chlebowczyk, Urszula
Cichy, Wojciech
Czaja-Bulsa, Grażyna
Socha, Jerzy
Atherosclerotic Risk Factors in Children with Celiac Disease
title Atherosclerotic Risk Factors in Children with Celiac Disease
title_full Atherosclerotic Risk Factors in Children with Celiac Disease
title_fullStr Atherosclerotic Risk Factors in Children with Celiac Disease
title_full_unstemmed Atherosclerotic Risk Factors in Children with Celiac Disease
title_short Atherosclerotic Risk Factors in Children with Celiac Disease
title_sort atherosclerotic risk factors in children with celiac disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140124/
https://www.ncbi.nlm.nih.gov/pubmed/32308675
http://dx.doi.org/10.1155/2020/6138243
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