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A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy

OBJECTIVE: To evaluate the impact of a novel interdisciplinary graduate-level course in chimeric antigenic receptor-T cell therapy on students’ knowledge and interests in translational science. MATERIALS/PARTICIPANTS AND METHODS: The course ran November 12 to 16, 2018. Students were surveyed before...

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Autores principales: Sterner, Rosalie M., Hedin, Karen E., Hayden, Richard E., Nowakowski, Grzegorz S., Wyles, Saranya P., Greenberg-Worisek, Alexandra J., Terzic, Andre, Kenderian, Saad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140137/
https://www.ncbi.nlm.nih.gov/pubmed/32280931
http://dx.doi.org/10.1016/j.mayocpiqo.2019.12.006
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author Sterner, Rosalie M.
Hedin, Karen E.
Hayden, Richard E.
Nowakowski, Grzegorz S.
Wyles, Saranya P.
Greenberg-Worisek, Alexandra J.
Terzic, Andre
Kenderian, Saad S.
author_facet Sterner, Rosalie M.
Hedin, Karen E.
Hayden, Richard E.
Nowakowski, Grzegorz S.
Wyles, Saranya P.
Greenberg-Worisek, Alexandra J.
Terzic, Andre
Kenderian, Saad S.
author_sort Sterner, Rosalie M.
collection PubMed
description OBJECTIVE: To evaluate the impact of a novel interdisciplinary graduate-level course in chimeric antigenic receptor-T cell therapy on students’ knowledge and interests in translational science. MATERIALS/PARTICIPANTS AND METHODS: The course ran November 12 to 16, 2018. Students were surveyed before and after the course. The survey included questions regarding background, self-perceived knowledge/confidence in skills, and interests/predicted behaviors. Students were assigned to work in collaborative interdisciplinary teams to develop a research proposal. RESULTS: A total of 25 students taking the course for graduate-level credit were surveyed. Of these, all 25 (100%) completed the surveys. Students came from variable backgrounds and were at different stages of graduate training. After completion of the course, there was a statistically significant increase in self-perceived knowledge of immunotherapy (mean score of 3.6 postcourse vs 2.6 precourse, on a 5-point Likert scale; P<.001), knowledge of the bench to clinic translational process (3.7 postcourse vs 3.0 precourse; P<.001), confidence in critical reading skills (4.3 postcourse vs 4.0 precourse; P=.008), confidence in immunotherapy-focused grant writing skills (3.6 postcourse vs 2.8 precourse; P<.001), and interest in working in interdisciplinary teams (4.8 postcourse vs 4.6 precourse; P=.02). CONCLUSION: The structure of this innovative and comprehensive course serves as a platform for educational courses in interdisciplinary translational research and helps trainees build knowledge and interest in the fields of chimeric antigenic receptor-T cells, regenerative sciences, and immunotherapy.
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spelling pubmed-71401372020-04-10 A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy Sterner, Rosalie M. Hedin, Karen E. Hayden, Richard E. Nowakowski, Grzegorz S. Wyles, Saranya P. Greenberg-Worisek, Alexandra J. Terzic, Andre Kenderian, Saad S. Mayo Clin Proc Innov Qual Outcomes Original Article OBJECTIVE: To evaluate the impact of a novel interdisciplinary graduate-level course in chimeric antigenic receptor-T cell therapy on students’ knowledge and interests in translational science. MATERIALS/PARTICIPANTS AND METHODS: The course ran November 12 to 16, 2018. Students were surveyed before and after the course. The survey included questions regarding background, self-perceived knowledge/confidence in skills, and interests/predicted behaviors. Students were assigned to work in collaborative interdisciplinary teams to develop a research proposal. RESULTS: A total of 25 students taking the course for graduate-level credit were surveyed. Of these, all 25 (100%) completed the surveys. Students came from variable backgrounds and were at different stages of graduate training. After completion of the course, there was a statistically significant increase in self-perceived knowledge of immunotherapy (mean score of 3.6 postcourse vs 2.6 precourse, on a 5-point Likert scale; P<.001), knowledge of the bench to clinic translational process (3.7 postcourse vs 3.0 precourse; P<.001), confidence in critical reading skills (4.3 postcourse vs 4.0 precourse; P=.008), confidence in immunotherapy-focused grant writing skills (3.6 postcourse vs 2.8 precourse; P<.001), and interest in working in interdisciplinary teams (4.8 postcourse vs 4.6 precourse; P=.02). CONCLUSION: The structure of this innovative and comprehensive course serves as a platform for educational courses in interdisciplinary translational research and helps trainees build knowledge and interest in the fields of chimeric antigenic receptor-T cells, regenerative sciences, and immunotherapy. Elsevier 2020-03-16 /pmc/articles/PMC7140137/ /pubmed/32280931 http://dx.doi.org/10.1016/j.mayocpiqo.2019.12.006 Text en © 2019 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Sterner, Rosalie M.
Hedin, Karen E.
Hayden, Richard E.
Nowakowski, Grzegorz S.
Wyles, Saranya P.
Greenberg-Worisek, Alexandra J.
Terzic, Andre
Kenderian, Saad S.
A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
title A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
title_full A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
title_fullStr A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
title_full_unstemmed A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
title_short A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
title_sort graduate-level interdisciplinary curriculum in car-t cell therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140137/
https://www.ncbi.nlm.nih.gov/pubmed/32280931
http://dx.doi.org/10.1016/j.mayocpiqo.2019.12.006
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