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Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors

BACKGROUND: Studies on the fusion-inhibitory peptides derived from the heptad repeat 1 and 2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial information on the viral fusogenic mechanism. We used a similar approach to study the fusogenic mechanism of severe-acute-respir...

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Detalles Bibliográficos
Autores principales:	Liu, Shuwen, Xiao, Gengfu, Chen, Yibang, He, Yuxian, Niu, Jinkui, Escalante, Carlos R, Xiong, Huabao, Farmar, James, Debnath, Asim K, Tien, Po, Jiang, Shibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140173/ https://www.ncbi.nlm.nih.gov/pubmed/15043961 http://dx.doi.org/10.1016/S0140-6736(04)15788-7

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