Yellow fever vector live-virus vaccines: West Nile virus vaccine development

By combining molecular-biological techniques with our increased understanding of the effect of gene sequence modification on viral function, yellow fever 17D, a positive-strand RNA virus vaccine, has been manipulated to induce a protective immune response against viruses of the same family (e.g. Jap...

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Detalles Bibliográficos
Autores principales: Arroyo, Juan, Miller, Charles A, Catalan, John, Monath, Thomas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140174/
https://www.ncbi.nlm.nih.gov/pubmed/11516995
http://dx.doi.org/10.1016/S1471-4914(01)02048-2
Descripción
Sumario:By combining molecular-biological techniques with our increased understanding of the effect of gene sequence modification on viral function, yellow fever 17D, a positive-strand RNA virus vaccine, has been manipulated to induce a protective immune response against viruses of the same family (e.g. Japanese encephalitis and dengue viruses). Triggered by the emergence of West Nile virus infections in the New World afflicting humans, horses and birds, the success of this recombinant technology has prompted the rapid development of a live-virus attenuated candidate vaccine against West Nile virus.

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