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Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review

H7N9 avian influenza virus (AIV) caused human infections in 2013 in China. Phylogenetic analyses indicate that H7N9 AIV is a novel reassortant strain with pandemic potential. We conducted a systemic review regarding virus-induced pathogenesis, vaccine development, and diagnosis of H7N9 AIV infection...

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Autores principales: Wang, Wen-Hung, Erazo, Esmeralda Merari, Ishcol, Max R. Chang, Lin, Chih-Yen, Assavalapsakul, Wanchai, Thitithanyanont, Arunee, Wang, Sheng-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140199/
https://www.ncbi.nlm.nih.gov/pubmed/31068040
http://dx.doi.org/10.1177/0300060519845488
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author Wang, Wen-Hung
Erazo, Esmeralda Merari
Ishcol, Max R. Chang
Lin, Chih-Yen
Assavalapsakul, Wanchai
Thitithanyanont, Arunee
Wang, Sheng-Fan
author_facet Wang, Wen-Hung
Erazo, Esmeralda Merari
Ishcol, Max R. Chang
Lin, Chih-Yen
Assavalapsakul, Wanchai
Thitithanyanont, Arunee
Wang, Sheng-Fan
author_sort Wang, Wen-Hung
collection PubMed
description H7N9 avian influenza virus (AIV) caused human infections in 2013 in China. Phylogenetic analyses indicate that H7N9 AIV is a novel reassortant strain with pandemic potential. We conducted a systemic review regarding virus-induced pathogenesis, vaccine development, and diagnosis of H7N9 AIV infection in humans. We followed PRISMA guidelines and searched PubMed, Web of Science, and Google Scholar to identify relevant articles published between January 2013 and December 2018. Pathogenesis data indicated that H7N9 AIV belongs to low pathogenic avian influenza, which is mostly asymptomatic in avian species; however, H7N9 induces high mortality in humans. Sporadic human infections have recently been reported, caused by highly pathogenic avian influenza viruses detected in poultry. H7N9 AIVs resistant to adamantine and oseltamivir cause severe human infection by rapidly inducing progressive acute community-acquired pneumonia, multiorgan dysfunction, and cytokine dysregulation; however, mechanisms via which the virus induces severe syndromes remain unclear. An H7N9 AIV vaccine is lacking; designs under evaluation include synthesized peptide, baculovirus-insect system, and virus-like particle vaccines. Molecular diagnosis of H7N9 AIVs is suggested over conventional assays, for biosafety reasons. Several advanced or modified diagnostic assays are under investigation and development. We summarized virus-induced pathogenesis, vaccine development, and current diagnostic assays in H7N9 AIVs.
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spelling pubmed-71401992020-04-13 Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review Wang, Wen-Hung Erazo, Esmeralda Merari Ishcol, Max R. Chang Lin, Chih-Yen Assavalapsakul, Wanchai Thitithanyanont, Arunee Wang, Sheng-Fan J Int Med Res Special Issue: Emerging and Reemerging Viral Disease H7N9 avian influenza virus (AIV) caused human infections in 2013 in China. Phylogenetic analyses indicate that H7N9 AIV is a novel reassortant strain with pandemic potential. We conducted a systemic review regarding virus-induced pathogenesis, vaccine development, and diagnosis of H7N9 AIV infection in humans. We followed PRISMA guidelines and searched PubMed, Web of Science, and Google Scholar to identify relevant articles published between January 2013 and December 2018. Pathogenesis data indicated that H7N9 AIV belongs to low pathogenic avian influenza, which is mostly asymptomatic in avian species; however, H7N9 induces high mortality in humans. Sporadic human infections have recently been reported, caused by highly pathogenic avian influenza viruses detected in poultry. H7N9 AIVs resistant to adamantine and oseltamivir cause severe human infection by rapidly inducing progressive acute community-acquired pneumonia, multiorgan dysfunction, and cytokine dysregulation; however, mechanisms via which the virus induces severe syndromes remain unclear. An H7N9 AIV vaccine is lacking; designs under evaluation include synthesized peptide, baculovirus-insect system, and virus-like particle vaccines. Molecular diagnosis of H7N9 AIVs is suggested over conventional assays, for biosafety reasons. Several advanced or modified diagnostic assays are under investigation and development. We summarized virus-induced pathogenesis, vaccine development, and current diagnostic assays in H7N9 AIVs. SAGE Publications 2019-05-08 /pmc/articles/PMC7140199/ /pubmed/31068040 http://dx.doi.org/10.1177/0300060519845488 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Special Issue: Emerging and Reemerging Viral Disease
Wang, Wen-Hung
Erazo, Esmeralda Merari
Ishcol, Max R. Chang
Lin, Chih-Yen
Assavalapsakul, Wanchai
Thitithanyanont, Arunee
Wang, Sheng-Fan
Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review
title Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review
title_full Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review
title_fullStr Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review
title_full_unstemmed Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review
title_short Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review
title_sort virus-induced pathogenesis, vaccine development, and diagnosis of novel h7n9 avian influenza a virus in humans: a systemic literature review
topic Special Issue: Emerging and Reemerging Viral Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140199/
https://www.ncbi.nlm.nih.gov/pubmed/31068040
http://dx.doi.org/10.1177/0300060519845488
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