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Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease

OBJECTIVE: Coronary artery disease (CAD) is the principal cause of mortality and morbidity worldwide. Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) are risk factors for CAD. In this study, we evaluated the r...

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Autores principales: Chiang, Shih-Min, Yang, Yi-Sun, Yang, Shun-Fa, Tsai, Chin-Feng, Ueng, Kwo-Chnag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140201/
https://www.ncbi.nlm.nih.gov/pubmed/30947598
http://dx.doi.org/10.1177/0300060519839519
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author Chiang, Shih-Min
Yang, Yi-Sun
Yang, Shun-Fa
Tsai, Chin-Feng
Ueng, Kwo-Chnag
author_facet Chiang, Shih-Min
Yang, Yi-Sun
Yang, Shun-Fa
Tsai, Chin-Feng
Ueng, Kwo-Chnag
author_sort Chiang, Shih-Min
collection PubMed
description OBJECTIVE: Coronary artery disease (CAD) is the principal cause of mortality and morbidity worldwide. Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) are risk factors for CAD. In this study, we evaluated the risk factors associated with PSCK9 genotypes and CAD in the Taiwanese population. METHODS: A total of 501 patients diagnosed with CAD by angiography and 334 CAD-free controls were recruited. Two single nucleotide polymorphisms of PSCK9 (rs505151 and rs529787) were genotyped. RESULTS: The prevalence of a positive family history for CAD was significantly higher in individuals carrying the AG + GG genotype of the PSCK9 rs505151 polymorphism. Among CAD patients with a positive family history, the prevalence of diabetes mellitus was significantly higher in those carrying the AG + GG genotype of the PSCK9 rs505151 polymorphism (73.3%) than in those carrying the AA genotype (39.2%). CONCLUSION: In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD.
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spelling pubmed-71402012020-04-13 Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease Chiang, Shih-Min Yang, Yi-Sun Yang, Shun-Fa Tsai, Chin-Feng Ueng, Kwo-Chnag J Int Med Res Special Issue: Advances in Cardiometabolic and Coronary Artery Disease OBJECTIVE: Coronary artery disease (CAD) is the principal cause of mortality and morbidity worldwide. Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) are risk factors for CAD. In this study, we evaluated the risk factors associated with PSCK9 genotypes and CAD in the Taiwanese population. METHODS: A total of 501 patients diagnosed with CAD by angiography and 334 CAD-free controls were recruited. Two single nucleotide polymorphisms of PSCK9 (rs505151 and rs529787) were genotyped. RESULTS: The prevalence of a positive family history for CAD was significantly higher in individuals carrying the AG + GG genotype of the PSCK9 rs505151 polymorphism. Among CAD patients with a positive family history, the prevalence of diabetes mellitus was significantly higher in those carrying the AG + GG genotype of the PSCK9 rs505151 polymorphism (73.3%) than in those carrying the AA genotype (39.2%). CONCLUSION: In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD. SAGE Publications 2019-04-05 /pmc/articles/PMC7140201/ /pubmed/30947598 http://dx.doi.org/10.1177/0300060519839519 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Special Issue: Advances in Cardiometabolic and Coronary Artery Disease
Chiang, Shih-Min
Yang, Yi-Sun
Yang, Shun-Fa
Tsai, Chin-Feng
Ueng, Kwo-Chnag
Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
title Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
title_full Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
title_fullStr Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
title_full_unstemmed Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
title_short Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
title_sort variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease
topic Special Issue: Advances in Cardiometabolic and Coronary Artery Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140201/
https://www.ncbi.nlm.nih.gov/pubmed/30947598
http://dx.doi.org/10.1177/0300060519839519
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