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Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population

OBJECTIVES: This study evaluated associations between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and diabetic retinopathy (DR) susceptibility within the Chinese population. METHODS: Five databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infr...

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Autores principales: Xu, Wei-hai, Zhuang, Ying, Han, Xiao, Yuan, Zhi-lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140216/
https://www.ncbi.nlm.nih.gov/pubmed/30628508
http://dx.doi.org/10.1177/0300060518816834
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author Xu, Wei-hai
Zhuang, Ying
Han, Xiao
Yuan, Zhi-lan
author_facet Xu, Wei-hai
Zhuang, Ying
Han, Xiao
Yuan, Zhi-lan
author_sort Xu, Wei-hai
collection PubMed
description OBJECTIVES: This study evaluated associations between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and diabetic retinopathy (DR) susceptibility within the Chinese population. METHODS: Five databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure) were used for literature searches of open access articles from inception through April 2017. RESULTS: Eight publications were identified involving 600 DR cases, 363 healthy controls, and 646 nondiabetic retinopathy (NDR) controls. There was a positive association between MTHFR C677T polymorphisms and DR risk within the Chinese population (DR with NDR controls: T vs. C, odds ratio (OR): 2.14, 95% confidence interval (CI): 1.55–2.97; TT vs. CC, OR: 4.19, 95% CI: 2.09–8.41; TT + CT vs. CC, OR: 2.83, 95% CI: 1.86–4.40; TT vs. CC + CT, OR: 2.48, 95% CI: 1.52–4.05. DR with healthy controls: T vs. C, OR: 2.48, 95% CI: 1.99–3.09; TT vs. CC, OR: 4.92, 95% CI: 3.18–7.62; TT + CT vs. CC, OR: 3.22, 95% CI: 2.32–4.48; TT vs. CC + CT, OR: 3.11, 95% CI: 1.83–5.28). The association was similar in South China and North China, when stratifying by geographic areas. CONCLUSION: MTHFR C677T polymorphisms increase DR risk within the Chinese population.
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spelling pubmed-71402162020-04-13 Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population Xu, Wei-hai Zhuang, Ying Han, Xiao Yuan, Zhi-lan J Int Med Res Meta-Analysis OBJECTIVES: This study evaluated associations between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and diabetic retinopathy (DR) susceptibility within the Chinese population. METHODS: Five databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure) were used for literature searches of open access articles from inception through April 2017. RESULTS: Eight publications were identified involving 600 DR cases, 363 healthy controls, and 646 nondiabetic retinopathy (NDR) controls. There was a positive association between MTHFR C677T polymorphisms and DR risk within the Chinese population (DR with NDR controls: T vs. C, odds ratio (OR): 2.14, 95% confidence interval (CI): 1.55–2.97; TT vs. CC, OR: 4.19, 95% CI: 2.09–8.41; TT + CT vs. CC, OR: 2.83, 95% CI: 1.86–4.40; TT vs. CC + CT, OR: 2.48, 95% CI: 1.52–4.05. DR with healthy controls: T vs. C, OR: 2.48, 95% CI: 1.99–3.09; TT vs. CC, OR: 4.92, 95% CI: 3.18–7.62; TT + CT vs. CC, OR: 3.22, 95% CI: 2.32–4.48; TT vs. CC + CT, OR: 3.11, 95% CI: 1.83–5.28). The association was similar in South China and North China, when stratifying by geographic areas. CONCLUSION: MTHFR C677T polymorphisms increase DR risk within the Chinese population. SAGE Publications 2019-01-10 /pmc/articles/PMC7140216/ /pubmed/30628508 http://dx.doi.org/10.1177/0300060518816834 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta-Analysis
Xu, Wei-hai
Zhuang, Ying
Han, Xiao
Yuan, Zhi-lan
Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
title Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
title_full Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
title_fullStr Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
title_full_unstemmed Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
title_short Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
title_sort methylenetetrahydrofolate reductase c677t polymorphism and diabetic retinopathy risk: a meta-analysis of the chinese population
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140216/
https://www.ncbi.nlm.nih.gov/pubmed/30628508
http://dx.doi.org/10.1177/0300060518816834
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