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Different associations between left atrial size and 2.5-year clinical outcomes in patients with anterior versus non-anterior wall ST-elevation myocardial infarction
OBJECTIVE: To investigate associations between left atrial diameter (LAD) and long-term outcomes in patients with anterior or non-anterior wall ST-elevation myocardial infarction (STEMI). METHODS: Patients with STEMI were included in this secondary analysis of data from a prospective cohort study in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140218/ https://www.ncbi.nlm.nih.gov/pubmed/32252575 http://dx.doi.org/10.1177/0300060520912073 |
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author | Gao, Fan Huo, Jianhua She, Jianqing Bai, Ling He, Hairong Lyu, Jun Qiang, Hua |
author_facet | Gao, Fan Huo, Jianhua She, Jianqing Bai, Ling He, Hairong Lyu, Jun Qiang, Hua |
author_sort | Gao, Fan |
collection | PubMed |
description | OBJECTIVE: To investigate associations between left atrial diameter (LAD) and long-term outcomes in patients with anterior or non-anterior wall ST-elevation myocardial infarction (STEMI). METHODS: Patients with STEMI were included in this secondary analysis of data from a prospective cohort study in which the primary outcome was major adverse cardiovascular event (MACE) occurrence during a 2.5-year follow-up. A LAD cut-off value was obtained through receiver operating characteristic curve analysis. Kaplan-Meier curve and Cox regression analyses were applied. Subgroup Cox regression analysis was also performed, with patients stratified based on left ventricular diastolic diameter (LVEDD, > 55 mm and ≤55 mm). The relationship between LAD and outcomes in patients with anterior or non-anterior wall STEMI was explored using restricted cubic spline functions. RESULTS: Out of 464 patients, adjusted Cox regression showed that dichotomous (>40 mm) LAD was significantly associated with MACE (hazard ratio 2.978, 95% confidence interval 1.763, 5.030) in patients with anterior wall but not non-anterior wall STEMI. The association was not different between normal and enlarged LVEDD groups. CONCLUSIONS: A left atrium > 40 mm may indicate higher risk of MACE in patients with anterior wall STEMI, even in patients with normal left ventricular structure. This relationship was not observed in patients with non-anterior wall STEMI. |
format | Online Article Text |
id | pubmed-7140218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-71402182020-04-13 Different associations between left atrial size and 2.5-year clinical outcomes in patients with anterior versus non-anterior wall ST-elevation myocardial infarction Gao, Fan Huo, Jianhua She, Jianqing Bai, Ling He, Hairong Lyu, Jun Qiang, Hua J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To investigate associations between left atrial diameter (LAD) and long-term outcomes in patients with anterior or non-anterior wall ST-elevation myocardial infarction (STEMI). METHODS: Patients with STEMI were included in this secondary analysis of data from a prospective cohort study in which the primary outcome was major adverse cardiovascular event (MACE) occurrence during a 2.5-year follow-up. A LAD cut-off value was obtained through receiver operating characteristic curve analysis. Kaplan-Meier curve and Cox regression analyses were applied. Subgroup Cox regression analysis was also performed, with patients stratified based on left ventricular diastolic diameter (LVEDD, > 55 mm and ≤55 mm). The relationship between LAD and outcomes in patients with anterior or non-anterior wall STEMI was explored using restricted cubic spline functions. RESULTS: Out of 464 patients, adjusted Cox regression showed that dichotomous (>40 mm) LAD was significantly associated with MACE (hazard ratio 2.978, 95% confidence interval 1.763, 5.030) in patients with anterior wall but not non-anterior wall STEMI. The association was not different between normal and enlarged LVEDD groups. CONCLUSIONS: A left atrium > 40 mm may indicate higher risk of MACE in patients with anterior wall STEMI, even in patients with normal left ventricular structure. This relationship was not observed in patients with non-anterior wall STEMI. SAGE Publications 2020-04-06 /pmc/articles/PMC7140218/ /pubmed/32252575 http://dx.doi.org/10.1177/0300060520912073 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Gao, Fan Huo, Jianhua She, Jianqing Bai, Ling He, Hairong Lyu, Jun Qiang, Hua Different associations between left atrial size and 2.5-year clinical outcomes in patients with anterior versus non-anterior wall ST-elevation myocardial infarction |
title | Different associations between left atrial size and 2.5-year clinical
outcomes in patients with anterior versus non-anterior wall ST-elevation
myocardial infarction |
title_full | Different associations between left atrial size and 2.5-year clinical
outcomes in patients with anterior versus non-anterior wall ST-elevation
myocardial infarction |
title_fullStr | Different associations between left atrial size and 2.5-year clinical
outcomes in patients with anterior versus non-anterior wall ST-elevation
myocardial infarction |
title_full_unstemmed | Different associations between left atrial size and 2.5-year clinical
outcomes in patients with anterior versus non-anterior wall ST-elevation
myocardial infarction |
title_short | Different associations between left atrial size and 2.5-year clinical
outcomes in patients with anterior versus non-anterior wall ST-elevation
myocardial infarction |
title_sort | different associations between left atrial size and 2.5-year clinical
outcomes in patients with anterior versus non-anterior wall st-elevation
myocardial infarction |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140218/ https://www.ncbi.nlm.nih.gov/pubmed/32252575 http://dx.doi.org/10.1177/0300060520912073 |
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