Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)

BACKGROUND: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) has been developed to assess upper extremity function of patients with multiple sclerosis (MS). A minimal clinically important difference (MCID) value has not been determined yet. OBJECTIVE: The objective of this study is to det...

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Autores principales: van Munster, Caspar EP, Kaya, Levent, Obura, Morgan, Kalkers, Nynke F, Uitdehaag, Bernard MJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140338/
https://www.ncbi.nlm.nih.gov/pubmed/30657002
http://dx.doi.org/10.1177/1352458518823489
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author van Munster, Caspar EP
Kaya, Levent
Obura, Morgan
Kalkers, Nynke F
Uitdehaag, Bernard MJ
author_facet van Munster, Caspar EP
Kaya, Levent
Obura, Morgan
Kalkers, Nynke F
Uitdehaag, Bernard MJ
author_sort van Munster, Caspar EP
collection PubMed
description BACKGROUND: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) has been developed to assess upper extremity function of patients with multiple sclerosis (MS). A minimal clinically important difference (MCID) value has not been determined yet. OBJECTIVE: The objective of this study is to determine an MCID for AMSQ. METHODS: We used the sensitivity- and specificity-based approach with dichotomized global perceived effect as an anchor. RESULTS: The receiver operating characteristic (ROC) curve yielded an optimal threshold value of 14.5 (sensitivity 0.68 and specificity 0.79). The area under the ROC curve value was 0.77. CONCLUSION: We identified an MCID of 15 points for the AMSQ (range 31–186).
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spelling pubmed-71403382020-04-17 Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ) van Munster, Caspar EP Kaya, Levent Obura, Morgan Kalkers, Nynke F Uitdehaag, Bernard MJ Mult Scler Short Reports BACKGROUND: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) has been developed to assess upper extremity function of patients with multiple sclerosis (MS). A minimal clinically important difference (MCID) value has not been determined yet. OBJECTIVE: The objective of this study is to determine an MCID for AMSQ. METHODS: We used the sensitivity- and specificity-based approach with dichotomized global perceived effect as an anchor. RESULTS: The receiver operating characteristic (ROC) curve yielded an optimal threshold value of 14.5 (sensitivity 0.68 and specificity 0.79). The area under the ROC curve value was 0.77. CONCLUSION: We identified an MCID of 15 points for the AMSQ (range 31–186). SAGE Publications 2019-01-18 2020-04 /pmc/articles/PMC7140338/ /pubmed/30657002 http://dx.doi.org/10.1177/1352458518823489 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Reports
van Munster, Caspar EP
Kaya, Levent
Obura, Morgan
Kalkers, Nynke F
Uitdehaag, Bernard MJ
Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
title Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
title_full Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
title_fullStr Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
title_full_unstemmed Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
title_short Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
title_sort minimal clinically important difference of improvement on the arm function in multiple sclerosis questionnaire (amsq)
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140338/
https://www.ncbi.nlm.nih.gov/pubmed/30657002
http://dx.doi.org/10.1177/1352458518823489
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