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Melatonin: new insights on its therapeutic properties in diabetic complications
Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/ https://www.ncbi.nlm.nih.gov/pubmed/32280378 http://dx.doi.org/10.1186/s13098-020-00537-z |
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author | Pourhanifeh, Mohammad Hossein Hosseinzadeh, Azam Dehdashtian, Ehsan Hemati, Karim Mehrzadi, Saeed |
author_facet | Pourhanifeh, Mohammad Hossein Hosseinzadeh, Azam Dehdashtian, Ehsan Hemati, Karim Mehrzadi, Saeed |
author_sort | Pourhanifeh, Mohammad Hossein |
collection | PubMed |
description | Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and anti-inflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications. |
format | Online Article Text |
id | pubmed-7140344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71403442020-04-11 Melatonin: new insights on its therapeutic properties in diabetic complications Pourhanifeh, Mohammad Hossein Hosseinzadeh, Azam Dehdashtian, Ehsan Hemati, Karim Mehrzadi, Saeed Diabetol Metab Syndr Review Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and anti-inflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications. BioMed Central 2020-04-08 /pmc/articles/PMC7140344/ /pubmed/32280378 http://dx.doi.org/10.1186/s13098-020-00537-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Pourhanifeh, Mohammad Hossein Hosseinzadeh, Azam Dehdashtian, Ehsan Hemati, Karim Mehrzadi, Saeed Melatonin: new insights on its therapeutic properties in diabetic complications |
title | Melatonin: new insights on its therapeutic properties in diabetic complications |
title_full | Melatonin: new insights on its therapeutic properties in diabetic complications |
title_fullStr | Melatonin: new insights on its therapeutic properties in diabetic complications |
title_full_unstemmed | Melatonin: new insights on its therapeutic properties in diabetic complications |
title_short | Melatonin: new insights on its therapeutic properties in diabetic complications |
title_sort | melatonin: new insights on its therapeutic properties in diabetic complications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/ https://www.ncbi.nlm.nih.gov/pubmed/32280378 http://dx.doi.org/10.1186/s13098-020-00537-z |
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