Melatonin: new insights on its therapeutic properties in diabetic complications

Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions....

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Detalles Bibliográficos
Autores principales: Pourhanifeh, Mohammad Hossein, Hosseinzadeh, Azam, Dehdashtian, Ehsan, Hemati, Karim, Mehrzadi, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/
https://www.ncbi.nlm.nih.gov/pubmed/32280378
http://dx.doi.org/10.1186/s13098-020-00537-z
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author Pourhanifeh, Mohammad Hossein
Hosseinzadeh, Azam
Dehdashtian, Ehsan
Hemati, Karim
Mehrzadi, Saeed
author_facet Pourhanifeh, Mohammad Hossein
Hosseinzadeh, Azam
Dehdashtian, Ehsan
Hemati, Karim
Mehrzadi, Saeed
author_sort Pourhanifeh, Mohammad Hossein
collection PubMed
description Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and anti-inflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications.
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spelling pubmed-71403442020-04-11 Melatonin: new insights on its therapeutic properties in diabetic complications Pourhanifeh, Mohammad Hossein Hosseinzadeh, Azam Dehdashtian, Ehsan Hemati, Karim Mehrzadi, Saeed Diabetol Metab Syndr Review Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and anti-inflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications. BioMed Central 2020-04-08 /pmc/articles/PMC7140344/ /pubmed/32280378 http://dx.doi.org/10.1186/s13098-020-00537-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Pourhanifeh, Mohammad Hossein
Hosseinzadeh, Azam
Dehdashtian, Ehsan
Hemati, Karim
Mehrzadi, Saeed
Melatonin: new insights on its therapeutic properties in diabetic complications
title Melatonin: new insights on its therapeutic properties in diabetic complications
title_full Melatonin: new insights on its therapeutic properties in diabetic complications
title_fullStr Melatonin: new insights on its therapeutic properties in diabetic complications
title_full_unstemmed Melatonin: new insights on its therapeutic properties in diabetic complications
title_short Melatonin: new insights on its therapeutic properties in diabetic complications
title_sort melatonin: new insights on its therapeutic properties in diabetic complications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/
https://www.ncbi.nlm.nih.gov/pubmed/32280378
http://dx.doi.org/10.1186/s13098-020-00537-z
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