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From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the b...

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Autores principales: Swenson, Samantha A., Moore, Courtney M., Marcero, Jason R., Medlock, Amy E., Reddi, Amit R., Khalimonchuk, Oleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140478/
https://www.ncbi.nlm.nih.gov/pubmed/32121449
http://dx.doi.org/10.3390/cells9030579
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author Swenson, Samantha A.
Moore, Courtney M.
Marcero, Jason R.
Medlock, Amy E.
Reddi, Amit R.
Khalimonchuk, Oleh
author_facet Swenson, Samantha A.
Moore, Courtney M.
Marcero, Jason R.
Medlock, Amy E.
Reddi, Amit R.
Khalimonchuk, Oleh
author_sort Swenson, Samantha A.
collection PubMed
description Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme—a highly reactive and inherently toxic compound—and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.
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spelling pubmed-71404782020-04-13 From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme Swenson, Samantha A. Moore, Courtney M. Marcero, Jason R. Medlock, Amy E. Reddi, Amit R. Khalimonchuk, Oleh Cells Review Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme—a highly reactive and inherently toxic compound—and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria. MDPI 2020-02-29 /pmc/articles/PMC7140478/ /pubmed/32121449 http://dx.doi.org/10.3390/cells9030579 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Swenson, Samantha A.
Moore, Courtney M.
Marcero, Jason R.
Medlock, Amy E.
Reddi, Amit R.
Khalimonchuk, Oleh
From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
title From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
title_full From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
title_fullStr From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
title_full_unstemmed From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
title_short From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
title_sort from synthesis to utilization: the ins and outs of mitochondrial heme
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140478/
https://www.ncbi.nlm.nih.gov/pubmed/32121449
http://dx.doi.org/10.3390/cells9030579
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