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From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140478/ https://www.ncbi.nlm.nih.gov/pubmed/32121449 http://dx.doi.org/10.3390/cells9030579 |
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author | Swenson, Samantha A. Moore, Courtney M. Marcero, Jason R. Medlock, Amy E. Reddi, Amit R. Khalimonchuk, Oleh |
author_facet | Swenson, Samantha A. Moore, Courtney M. Marcero, Jason R. Medlock, Amy E. Reddi, Amit R. Khalimonchuk, Oleh |
author_sort | Swenson, Samantha A. |
collection | PubMed |
description | Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme—a highly reactive and inherently toxic compound—and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria. |
format | Online Article Text |
id | pubmed-7140478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71404782020-04-13 From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme Swenson, Samantha A. Moore, Courtney M. Marcero, Jason R. Medlock, Amy E. Reddi, Amit R. Khalimonchuk, Oleh Cells Review Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme—a highly reactive and inherently toxic compound—and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria. MDPI 2020-02-29 /pmc/articles/PMC7140478/ /pubmed/32121449 http://dx.doi.org/10.3390/cells9030579 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Swenson, Samantha A. Moore, Courtney M. Marcero, Jason R. Medlock, Amy E. Reddi, Amit R. Khalimonchuk, Oleh From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme |
title | From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme |
title_full | From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme |
title_fullStr | From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme |
title_full_unstemmed | From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme |
title_short | From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme |
title_sort | from synthesis to utilization: the ins and outs of mitochondrial heme |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140478/ https://www.ncbi.nlm.nih.gov/pubmed/32121449 http://dx.doi.org/10.3390/cells9030579 |
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