Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions

The inhibition of mitochondrial permeabilization by the anti-apoptotic protein Bcl-xL is crucial for cell survival and homeostasis. Its inhibitory role requires the partitioning of Bcl-xL to the mitochondrial outer membrane from an inactive state in the cytosol, leading to its extensive refolding. T...

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Detalles Bibliográficos
Autores principales: Vasquez-Montes, Victor, Kyrychenko, Alexander, Vargas-Uribe, Mauricio, Rodnin, Mykola V., Ladokhin, Alexey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140517/
https://www.ncbi.nlm.nih.gov/pubmed/32111007
http://dx.doi.org/10.3390/cells9030539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140517/
https://www.ncbi.nlm.nih.gov/pubmed/32111007
http://dx.doi.org/10.3390/cells9030539

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