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Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine
Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140531/ https://www.ncbi.nlm.nih.gov/pubmed/32121221 http://dx.doi.org/10.3390/cells9030573 |
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author | Bento, Guida Shafigullina, Aygul K. Rizvanov, Albert A. Sardão, Vilma A. Macedo, Maria Paula Oliveira, Paulo J. |
author_facet | Bento, Guida Shafigullina, Aygul K. Rizvanov, Albert A. Sardão, Vilma A. Macedo, Maria Paula Oliveira, Paulo J. |
author_sort | Bento, Guida |
collection | PubMed |
description | Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC. |
format | Online Article Text |
id | pubmed-7140531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71405312020-04-13 Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine Bento, Guida Shafigullina, Aygul K. Rizvanov, Albert A. Sardão, Vilma A. Macedo, Maria Paula Oliveira, Paulo J. Cells Review Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC. MDPI 2020-02-28 /pmc/articles/PMC7140531/ /pubmed/32121221 http://dx.doi.org/10.3390/cells9030573 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bento, Guida Shafigullina, Aygul K. Rizvanov, Albert A. Sardão, Vilma A. Macedo, Maria Paula Oliveira, Paulo J. Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine |
title | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine |
title_full | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine |
title_fullStr | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine |
title_full_unstemmed | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine |
title_short | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine |
title_sort | urine-derived stem cells: applications in regenerative and predictive medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140531/ https://www.ncbi.nlm.nih.gov/pubmed/32121221 http://dx.doi.org/10.3390/cells9030573 |
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