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Human biologic monitoring based on blood donations to the National Blood Services
BACKGROUND: The ambient exposure does not always reflect the internal levels of pollution absorbed in the body. While human biomonitoring (HBM) could provide a valid estimate of exposure extent, it is usually an expensive and a heavily manpowered enterprise. Using samples collected during blood dona...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140578/ https://www.ncbi.nlm.nih.gov/pubmed/32268895 http://dx.doi.org/10.1186/s12889-020-08588-7 |
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author | Hassan, Lior Moser, Asher Rorman, Efrat Groisman, Luda Naor, Yamit Shinar, Eilat Gat, Roni Jaffe, Eli Novack, Victor Kloog, Itai Novack, Lena |
author_facet | Hassan, Lior Moser, Asher Rorman, Efrat Groisman, Luda Naor, Yamit Shinar, Eilat Gat, Roni Jaffe, Eli Novack, Victor Kloog, Itai Novack, Lena |
author_sort | Hassan, Lior |
collection | PubMed |
description | BACKGROUND: The ambient exposure does not always reflect the internal levels of pollution absorbed in the body. While human biomonitoring (HBM) could provide a valid estimate of exposure extent, it is usually an expensive and a heavily manpowered enterprise. Using samples collected during blood donations for HMB may provide a more efficient platform for a routine biomonitoring. METHODS: The current study is aimed to explore the feasibility of using the national blood banking system for the purposes of HBM, to compare between residents of a suspected polluted area in northern Israel (Haifa Bay) to the rest of the country. Specifically, we will assemble a geographically representative sample of blood donors residing in the study area and of the general population, to test for four industry and traffic-related metals: lead (Pb), cadmium (Cd), arsenic (As) and chromium (Cr). Samples of whole blood from donors will be tested in the Laboratory of Public Health Services managed by the Ministry of Health. The information on donors’ biomarkers levels will be further linked with the air pollution and meteorological data assessed at the location of the blood collection sites (short-term exposure) and donors’ permanent address (long-term exposure), as recorded by the monitoring stations spread throughout Israel and the satellite-based exposure models. The association between biomarkers and ambient environmental exposures will be assessed. The samples’ collection is planned for 2 years of 2020–2021. DISCUSSION: The information collected in this study could lead to environmental regulations within Haifa Bay area aimed to prevent exposure to high levels of hazardous chemicals. |
format | Online Article Text |
id | pubmed-7140578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71405782020-04-14 Human biologic monitoring based on blood donations to the National Blood Services Hassan, Lior Moser, Asher Rorman, Efrat Groisman, Luda Naor, Yamit Shinar, Eilat Gat, Roni Jaffe, Eli Novack, Victor Kloog, Itai Novack, Lena BMC Public Health Study Protocol BACKGROUND: The ambient exposure does not always reflect the internal levels of pollution absorbed in the body. While human biomonitoring (HBM) could provide a valid estimate of exposure extent, it is usually an expensive and a heavily manpowered enterprise. Using samples collected during blood donations for HMB may provide a more efficient platform for a routine biomonitoring. METHODS: The current study is aimed to explore the feasibility of using the national blood banking system for the purposes of HBM, to compare between residents of a suspected polluted area in northern Israel (Haifa Bay) to the rest of the country. Specifically, we will assemble a geographically representative sample of blood donors residing in the study area and of the general population, to test for four industry and traffic-related metals: lead (Pb), cadmium (Cd), arsenic (As) and chromium (Cr). Samples of whole blood from donors will be tested in the Laboratory of Public Health Services managed by the Ministry of Health. The information on donors’ biomarkers levels will be further linked with the air pollution and meteorological data assessed at the location of the blood collection sites (short-term exposure) and donors’ permanent address (long-term exposure), as recorded by the monitoring stations spread throughout Israel and the satellite-based exposure models. The association between biomarkers and ambient environmental exposures will be assessed. The samples’ collection is planned for 2 years of 2020–2021. DISCUSSION: The information collected in this study could lead to environmental regulations within Haifa Bay area aimed to prevent exposure to high levels of hazardous chemicals. BioMed Central 2020-04-08 /pmc/articles/PMC7140578/ /pubmed/32268895 http://dx.doi.org/10.1186/s12889-020-08588-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Hassan, Lior Moser, Asher Rorman, Efrat Groisman, Luda Naor, Yamit Shinar, Eilat Gat, Roni Jaffe, Eli Novack, Victor Kloog, Itai Novack, Lena Human biologic monitoring based on blood donations to the National Blood Services |
title | Human biologic monitoring based on blood donations to the National Blood Services |
title_full | Human biologic monitoring based on blood donations to the National Blood Services |
title_fullStr | Human biologic monitoring based on blood donations to the National Blood Services |
title_full_unstemmed | Human biologic monitoring based on blood donations to the National Blood Services |
title_short | Human biologic monitoring based on blood donations to the National Blood Services |
title_sort | human biologic monitoring based on blood donations to the national blood services |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140578/ https://www.ncbi.nlm.nih.gov/pubmed/32268895 http://dx.doi.org/10.1186/s12889-020-08588-7 |
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