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Revisiting the Interaction of γδ T-Cells and B-Cells
Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140609/ https://www.ncbi.nlm.nih.gov/pubmed/32197382 http://dx.doi.org/10.3390/cells9030743 |
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author | Rampoldi, Francesca Ullrich, Leon Prinz, Immo |
author_facet | Rampoldi, Francesca Ullrich, Leon Prinz, Immo |
author_sort | Rampoldi, Francesca |
collection | PubMed |
description | Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against “self” and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity. |
format | Online Article Text |
id | pubmed-7140609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71406092020-04-13 Revisiting the Interaction of γδ T-Cells and B-Cells Rampoldi, Francesca Ullrich, Leon Prinz, Immo Cells Review Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against “self” and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity. MDPI 2020-03-18 /pmc/articles/PMC7140609/ /pubmed/32197382 http://dx.doi.org/10.3390/cells9030743 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rampoldi, Francesca Ullrich, Leon Prinz, Immo Revisiting the Interaction of γδ T-Cells and B-Cells |
title | Revisiting the Interaction of γδ T-Cells and B-Cells |
title_full | Revisiting the Interaction of γδ T-Cells and B-Cells |
title_fullStr | Revisiting the Interaction of γδ T-Cells and B-Cells |
title_full_unstemmed | Revisiting the Interaction of γδ T-Cells and B-Cells |
title_short | Revisiting the Interaction of γδ T-Cells and B-Cells |
title_sort | revisiting the interaction of γδ t-cells and b-cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140609/ https://www.ncbi.nlm.nih.gov/pubmed/32197382 http://dx.doi.org/10.3390/cells9030743 |
work_keys_str_mv | AT rampoldifrancesca revisitingtheinteractionofgdtcellsandbcells AT ullrichleon revisitingtheinteractionofgdtcellsandbcells AT prinzimmo revisitingtheinteractionofgdtcellsandbcells |