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Revisiting the Interaction of γδ T-Cells and B-Cells

Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence o...

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Detalles Bibliográficos
Autores principales: Rampoldi, Francesca, Ullrich, Leon, Prinz, Immo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140609/
https://www.ncbi.nlm.nih.gov/pubmed/32197382
http://dx.doi.org/10.3390/cells9030743
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author Rampoldi, Francesca
Ullrich, Leon
Prinz, Immo
author_facet Rampoldi, Francesca
Ullrich, Leon
Prinz, Immo
author_sort Rampoldi, Francesca
collection PubMed
description Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against “self” and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity.
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spelling pubmed-71406092020-04-13 Revisiting the Interaction of γδ T-Cells and B-Cells Rampoldi, Francesca Ullrich, Leon Prinz, Immo Cells Review Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against “self” and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity. MDPI 2020-03-18 /pmc/articles/PMC7140609/ /pubmed/32197382 http://dx.doi.org/10.3390/cells9030743 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rampoldi, Francesca
Ullrich, Leon
Prinz, Immo
Revisiting the Interaction of γδ T-Cells and B-Cells
title Revisiting the Interaction of γδ T-Cells and B-Cells
title_full Revisiting the Interaction of γδ T-Cells and B-Cells
title_fullStr Revisiting the Interaction of γδ T-Cells and B-Cells
title_full_unstemmed Revisiting the Interaction of γδ T-Cells and B-Cells
title_short Revisiting the Interaction of γδ T-Cells and B-Cells
title_sort revisiting the interaction of γδ t-cells and b-cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140609/
https://www.ncbi.nlm.nih.gov/pubmed/32197382
http://dx.doi.org/10.3390/cells9030743
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