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Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus

Gestational diabetes Mellitus (GDM) is a complex clinical condition that promotes pelvic floor myopathy, thus predisposing sufferers to urinary incontinence (UI). GDM usually regresses after birth. Nonetheless, a GDM history is associated with higher risk of subsequently developing type 2 diabetes,...

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Autores principales: Floriano, Juliana Ferreira, Willis, Gareth, Catapano, Francesco, de Lima, Patrícia Rodrigues, Reis, Fabiana Vieira Duarte Souza, Barbosa, Angélica Mercia Pascon, Rudge, Marilza Vieira Cunha, Emanueli, Costanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140615/
https://www.ncbi.nlm.nih.gov/pubmed/32164322
http://dx.doi.org/10.3390/cells9030675
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author Floriano, Juliana Ferreira
Willis, Gareth
Catapano, Francesco
de Lima, Patrícia Rodrigues
Reis, Fabiana Vieira Duarte Souza
Barbosa, Angélica Mercia Pascon
Rudge, Marilza Vieira Cunha
Emanueli, Costanza
author_facet Floriano, Juliana Ferreira
Willis, Gareth
Catapano, Francesco
de Lima, Patrícia Rodrigues
Reis, Fabiana Vieira Duarte Souza
Barbosa, Angélica Mercia Pascon
Rudge, Marilza Vieira Cunha
Emanueli, Costanza
author_sort Floriano, Juliana Ferreira
collection PubMed
description Gestational diabetes Mellitus (GDM) is a complex clinical condition that promotes pelvic floor myopathy, thus predisposing sufferers to urinary incontinence (UI). GDM usually regresses after birth. Nonetheless, a GDM history is associated with higher risk of subsequently developing type 2 diabetes, cardiovascular diseases (CVD) and UI. Some aspects of the pathophysiology of GDM remain unclear and the associated pathologies (outcomes) are poorly addressed, simultaneously raising public health costs and diminishing women’s quality of life. Exosomes are small extracellular vesicles produced and actively secreted by cells as part of their intercellular communication system. Exosomes are heterogenous in their cargo and depending on the cell sources and environment, they can mediate both pathogenetic and therapeutic functions. With the advancement in knowledge of exosomes, new perspectives have emerged to support the mechanistic understanding, prediction/diagnosis and ultimately, treatment of the post-GMD outcomes. Here, we will review recent advances in knowledge of the role of exosomes in GDM and related areas and discuss the possibilities for translating exosomes as therapeutic agents in the GDM clinical setting.
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spelling pubmed-71406152020-04-13 Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus Floriano, Juliana Ferreira Willis, Gareth Catapano, Francesco de Lima, Patrícia Rodrigues Reis, Fabiana Vieira Duarte Souza Barbosa, Angélica Mercia Pascon Rudge, Marilza Vieira Cunha Emanueli, Costanza Cells Review Gestational diabetes Mellitus (GDM) is a complex clinical condition that promotes pelvic floor myopathy, thus predisposing sufferers to urinary incontinence (UI). GDM usually regresses after birth. Nonetheless, a GDM history is associated with higher risk of subsequently developing type 2 diabetes, cardiovascular diseases (CVD) and UI. Some aspects of the pathophysiology of GDM remain unclear and the associated pathologies (outcomes) are poorly addressed, simultaneously raising public health costs and diminishing women’s quality of life. Exosomes are small extracellular vesicles produced and actively secreted by cells as part of their intercellular communication system. Exosomes are heterogenous in their cargo and depending on the cell sources and environment, they can mediate both pathogenetic and therapeutic functions. With the advancement in knowledge of exosomes, new perspectives have emerged to support the mechanistic understanding, prediction/diagnosis and ultimately, treatment of the post-GMD outcomes. Here, we will review recent advances in knowledge of the role of exosomes in GDM and related areas and discuss the possibilities for translating exosomes as therapeutic agents in the GDM clinical setting. MDPI 2020-03-10 /pmc/articles/PMC7140615/ /pubmed/32164322 http://dx.doi.org/10.3390/cells9030675 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Floriano, Juliana Ferreira
Willis, Gareth
Catapano, Francesco
de Lima, Patrícia Rodrigues
Reis, Fabiana Vieira Duarte Souza
Barbosa, Angélica Mercia Pascon
Rudge, Marilza Vieira Cunha
Emanueli, Costanza
Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
title Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
title_full Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
title_fullStr Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
title_full_unstemmed Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
title_short Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
title_sort exosomes could offer new options to combat the long-term complications inflicted by gestational diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140615/
https://www.ncbi.nlm.nih.gov/pubmed/32164322
http://dx.doi.org/10.3390/cells9030675
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