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The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance
While forming a minor population in the blood and lymphoid compartments, γδ T cells are significantly enriched within barrier tissues. In addition to providing protection against infection, these tissue-resident γδ T cells play critical roles in tissue homeostasis and repair. γδ T cells in the epide...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140644/ https://www.ncbi.nlm.nih.gov/pubmed/32168884 http://dx.doi.org/10.3390/cells9030686 |
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author | Johnson, Margarete D. Witherden, Deborah A. Havran, Wendy L. |
author_facet | Johnson, Margarete D. Witherden, Deborah A. Havran, Wendy L. |
author_sort | Johnson, Margarete D. |
collection | PubMed |
description | While forming a minor population in the blood and lymphoid compartments, γδ T cells are significantly enriched within barrier tissues. In addition to providing protection against infection, these tissue-resident γδ T cells play critical roles in tissue homeostasis and repair. γδ T cells in the epidermis and intestinal epithelium produce growth factors and cytokines that are important for the normal turnover and maintenance of surrounding epithelial cells and are additionally required for the efficient recognition of, and response to, tissue damage. A role for tissue-resident γδ T cells is emerging outside of the traditional barrier tissues as well, with recent research indicating that adipose tissue-resident γδ T cells are required for the normal maintenance and function of the adipose tissue compartment. Here we review the functions of tissue-resident γδ T cells in the epidermis, intestinal epithelium, and adipose tissue, and compare the mechanisms of their activation between these sites. |
format | Online Article Text |
id | pubmed-7140644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71406442020-04-13 The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance Johnson, Margarete D. Witherden, Deborah A. Havran, Wendy L. Cells Review While forming a minor population in the blood and lymphoid compartments, γδ T cells are significantly enriched within barrier tissues. In addition to providing protection against infection, these tissue-resident γδ T cells play critical roles in tissue homeostasis and repair. γδ T cells in the epidermis and intestinal epithelium produce growth factors and cytokines that are important for the normal turnover and maintenance of surrounding epithelial cells and are additionally required for the efficient recognition of, and response to, tissue damage. A role for tissue-resident γδ T cells is emerging outside of the traditional barrier tissues as well, with recent research indicating that adipose tissue-resident γδ T cells are required for the normal maintenance and function of the adipose tissue compartment. Here we review the functions of tissue-resident γδ T cells in the epidermis, intestinal epithelium, and adipose tissue, and compare the mechanisms of their activation between these sites. MDPI 2020-03-11 /pmc/articles/PMC7140644/ /pubmed/32168884 http://dx.doi.org/10.3390/cells9030686 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Johnson, Margarete D. Witherden, Deborah A. Havran, Wendy L. The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance |
title | The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance |
title_full | The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance |
title_fullStr | The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance |
title_full_unstemmed | The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance |
title_short | The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance |
title_sort | role of tissue-resident γδ t cells in stress surveillance and tissue maintenance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140644/ https://www.ncbi.nlm.nih.gov/pubmed/32168884 http://dx.doi.org/10.3390/cells9030686 |
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