Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment

Cardiovascular disease (CVD) is the main cause of death worldwide, and aging is its leading risk factor. Aging is much accelerated in Hutchinson–Gilford progeria syndrome (HGPS), an ultra-rare genetic disorder provoked by the ubiquitous expression of a mutant protein called progerin. HGPS patients d...

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Detalles Bibliográficos
Autores principales: del Campo, Lara, Sánchez-López, Amanda, González-Gómez, Cristina, Andrés-Manzano, María Jesús, Dorado, Beatriz, Andrés, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140649/
https://www.ncbi.nlm.nih.gov/pubmed/32182706
http://dx.doi.org/10.3390/cells9030656

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