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STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model

Constitutively activated STAT3 plays an essential role in the initiation, progression, maintenance, malignancy, and drug resistance of cancer, including glioblastoma, suggesting that STAT3 is a potential therapeutic target for cancer therapy. We recently identified ODZ10117 as a small molecule inhib...

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Autores principales: Kim, Byung-Hak, Lee, Haeri, Park, Cheol Gyu, Jeong, Ae Jin, Lee, Song-Hee, Noh, Kum Hee, Park, Jong Bae, Lee, Chung-Gi, Paek, Sun Ha, Kim, Hyunggee, Ye, Sang-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140655/
https://www.ncbi.nlm.nih.gov/pubmed/32183406
http://dx.doi.org/10.3390/cells9030722
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author Kim, Byung-Hak
Lee, Haeri
Park, Cheol Gyu
Jeong, Ae Jin
Lee, Song-Hee
Noh, Kum Hee
Park, Jong Bae
Lee, Chung-Gi
Paek, Sun Ha
Kim, Hyunggee
Ye, Sang-Kyu
author_facet Kim, Byung-Hak
Lee, Haeri
Park, Cheol Gyu
Jeong, Ae Jin
Lee, Song-Hee
Noh, Kum Hee
Park, Jong Bae
Lee, Chung-Gi
Paek, Sun Ha
Kim, Hyunggee
Ye, Sang-Kyu
author_sort Kim, Byung-Hak
collection PubMed
description Constitutively activated STAT3 plays an essential role in the initiation, progression, maintenance, malignancy, and drug resistance of cancer, including glioblastoma, suggesting that STAT3 is a potential therapeutic target for cancer therapy. We recently identified ODZ10117 as a small molecule inhibitor of STAT3 and suggested that it may have an effective therapeutic utility for the STAT3-targeted cancer therapy. Here, we demonstrated the therapeutic efficacy of ODZ10117 in glioblastoma by targeting STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells and patient-derived primary glioblastoma cells. In addition, ODZ10117 suppressed stem cell properties in glioma stem cells (GSCs). Finally, the administration of ODZ10117 showed significant therapeutic efficacy in mouse xenograft models of GSCs and glioblastoma cells. Collectively, ODZ10117 is a promising therapeutic candidate for glioblastoma by targeting STAT3.
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spelling pubmed-71406552020-04-13 STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model Kim, Byung-Hak Lee, Haeri Park, Cheol Gyu Jeong, Ae Jin Lee, Song-Hee Noh, Kum Hee Park, Jong Bae Lee, Chung-Gi Paek, Sun Ha Kim, Hyunggee Ye, Sang-Kyu Cells Article Constitutively activated STAT3 plays an essential role in the initiation, progression, maintenance, malignancy, and drug resistance of cancer, including glioblastoma, suggesting that STAT3 is a potential therapeutic target for cancer therapy. We recently identified ODZ10117 as a small molecule inhibitor of STAT3 and suggested that it may have an effective therapeutic utility for the STAT3-targeted cancer therapy. Here, we demonstrated the therapeutic efficacy of ODZ10117 in glioblastoma by targeting STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells and patient-derived primary glioblastoma cells. In addition, ODZ10117 suppressed stem cell properties in glioma stem cells (GSCs). Finally, the administration of ODZ10117 showed significant therapeutic efficacy in mouse xenograft models of GSCs and glioblastoma cells. Collectively, ODZ10117 is a promising therapeutic candidate for glioblastoma by targeting STAT3. MDPI 2020-03-15 /pmc/articles/PMC7140655/ /pubmed/32183406 http://dx.doi.org/10.3390/cells9030722 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Byung-Hak
Lee, Haeri
Park, Cheol Gyu
Jeong, Ae Jin
Lee, Song-Hee
Noh, Kum Hee
Park, Jong Bae
Lee, Chung-Gi
Paek, Sun Ha
Kim, Hyunggee
Ye, Sang-Kyu
STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
title STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
title_full STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
title_fullStr STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
title_full_unstemmed STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
title_short STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
title_sort stat3 inhibitor odz10117 suppresses glioblastoma malignancy and prolongs survival in a glioblastoma xenograft model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140655/
https://www.ncbi.nlm.nih.gov/pubmed/32183406
http://dx.doi.org/10.3390/cells9030722
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