Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, inductio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Lei, Liu, Xiaotian, Shi, Yinghong, Ocansey, Dickson Kofi Wiredu, Hu, Yuyan, Li, Xiaoxi, Zhang, Chenxiao, Xu, Wenrong, Qian, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140663/
https://www.ncbi.nlm.nih.gov/pubmed/32183102
http://dx.doi.org/10.3390/cells9030707
Descripción
Sumario:Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.

Ejemplares similares