Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, inductio...

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Autores principales: Yin, Lei, Liu, Xiaotian, Shi, Yinghong, Ocansey, Dickson Kofi Wiredu, Hu, Yuyan, Li, Xiaoxi, Zhang, Chenxiao, Xu, Wenrong, Qian, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140663/
https://www.ncbi.nlm.nih.gov/pubmed/32183102
http://dx.doi.org/10.3390/cells9030707
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author Yin, Lei
Liu, Xiaotian
Shi, Yinghong
Ocansey, Dickson Kofi Wiredu
Hu, Yuyan
Li, Xiaoxi
Zhang, Chenxiao
Xu, Wenrong
Qian, Hui
author_facet Yin, Lei
Liu, Xiaotian
Shi, Yinghong
Ocansey, Dickson Kofi Wiredu
Hu, Yuyan
Li, Xiaoxi
Zhang, Chenxiao
Xu, Wenrong
Qian, Hui
author_sort Yin, Lei
collection PubMed
description Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.
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spelling pubmed-71406632020-04-13 Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine Yin, Lei Liu, Xiaotian Shi, Yinghong Ocansey, Dickson Kofi Wiredu Hu, Yuyan Li, Xiaoxi Zhang, Chenxiao Xu, Wenrong Qian, Hui Cells Review Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules. MDPI 2020-03-13 /pmc/articles/PMC7140663/ /pubmed/32183102 http://dx.doi.org/10.3390/cells9030707 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yin, Lei
Liu, Xiaotian
Shi, Yinghong
Ocansey, Dickson Kofi Wiredu
Hu, Yuyan
Li, Xiaoxi
Zhang, Chenxiao
Xu, Wenrong
Qian, Hui
Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine
title Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine
title_full Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine
title_fullStr Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine
title_full_unstemmed Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine
title_short Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine
title_sort therapeutic advances of stem cell-derived extracellular vesicles in regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140663/
https://www.ncbi.nlm.nih.gov/pubmed/32183102
http://dx.doi.org/10.3390/cells9030707
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