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Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly und...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140710/ https://www.ncbi.nlm.nih.gov/pubmed/32192015 http://dx.doi.org/10.3390/cells9030733 |
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author | Frasch, Martin G. Giussani, Dino A. |
author_facet | Frasch, Martin G. Giussani, Dino A. |
author_sort | Frasch, Martin G. |
collection | PubMed |
description | Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease. |
format | Online Article Text |
id | pubmed-7140710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71407102020-04-13 Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development Frasch, Martin G. Giussani, Dino A. Cells Review Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease. MDPI 2020-03-17 /pmc/articles/PMC7140710/ /pubmed/32192015 http://dx.doi.org/10.3390/cells9030733 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frasch, Martin G. Giussani, Dino A. Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
title | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
title_full | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
title_fullStr | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
title_full_unstemmed | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
title_short | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
title_sort | impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140710/ https://www.ncbi.nlm.nih.gov/pubmed/32192015 http://dx.doi.org/10.3390/cells9030733 |
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