Important Steps to Control COVID-19/SARS-CoV-2 Infection

Elderly patients are having high mortality rates from COVID-19/SARS-CoV-2 infection compared to younger patients. The SARS-CoV-2 virus uses the ACE2 receptor as the entry point to the host cells. ARBs/ACEIs which are widely used in elderly patients, have been found to be associated with overexpressi...

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Detalles Bibliográficos
Autor principal: Chatterjee, Sudipto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Covid-19
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140724/
https://www.ncbi.nlm.nih.gov/pubmed/32292884
http://dx.doi.org/10.1007/s42399-020-00271-7
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author Chatterjee, Sudipto
author_facet Chatterjee, Sudipto
author_sort Chatterjee, Sudipto
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description Elderly patients are having high mortality rates from COVID-19/SARS-CoV-2 infection compared to younger patients. The SARS-CoV-2 virus uses the ACE2 receptor as the entry point to the host cells. ARBs/ACEIs which are widely used in elderly patients, have been found to be associated with overexpression of ACE2.To decrease the severity of COVID-19 infection, ARB/ACEI should be switched to another class drug not known to cause a rise in ACE2 until the COVID-19 infection subsides. Specific human immunoglobulin can be tried for COVID-19 patients with critical conditions under supervision.
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spelling pubmed-71407242020-04-08 Important Steps to Control COVID-19/SARS-CoV-2 Infection Chatterjee, Sudipto SN Compr Clin Med Covid-19 Elderly patients are having high mortality rates from COVID-19/SARS-CoV-2 infection compared to younger patients. The SARS-CoV-2 virus uses the ACE2 receptor as the entry point to the host cells. ARBs/ACEIs which are widely used in elderly patients, have been found to be associated with overexpression of ACE2.To decrease the severity of COVID-19 infection, ARB/ACEI should be switched to another class drug not known to cause a rise in ACE2 until the COVID-19 infection subsides. Specific human immunoglobulin can be tried for COVID-19 patients with critical conditions under supervision. Springer International Publishing 2020-04-08 2020 /pmc/articles/PMC7140724/ /pubmed/32292884 http://dx.doi.org/10.1007/s42399-020-00271-7 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
Chatterjee, Sudipto
Important Steps to Control COVID-19/SARS-CoV-2 Infection
title Important Steps to Control COVID-19/SARS-CoV-2 Infection
title_full Important Steps to Control COVID-19/SARS-CoV-2 Infection
title_fullStr Important Steps to Control COVID-19/SARS-CoV-2 Infection
title_full_unstemmed Important Steps to Control COVID-19/SARS-CoV-2 Infection
title_short Important Steps to Control COVID-19/SARS-CoV-2 Infection
title_sort important steps to control covid-19/sars-cov-2 infection
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140724/
https://www.ncbi.nlm.nih.gov/pubmed/32292884
http://dx.doi.org/10.1007/s42399-020-00271-7
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