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Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence i...

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Autores principales: Amaya-Montoya, Mateo, Pérez-Londoño, Agustín, Guatibonza-García, Valentina, Vargas-Villanueva, Andrea, Mendivil, Carlos O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140757/
https://www.ncbi.nlm.nih.gov/pubmed/32185730
http://dx.doi.org/10.1007/s12325-020-01287-0
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author Amaya-Montoya, Mateo
Pérez-Londoño, Agustín
Guatibonza-García, Valentina
Vargas-Villanueva, Andrea
Mendivil, Carlos O.
author_facet Amaya-Montoya, Mateo
Pérez-Londoño, Agustín
Guatibonza-García, Valentina
Vargas-Villanueva, Andrea
Mendivil, Carlos O.
author_sort Amaya-Montoya, Mateo
collection PubMed
description Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell cycle arrest with suppressed apoptosis and concomitant secretion of multiple bioactive factors (the senescence-associated secretory phenotype—SASP) that plays a physiological role in embryonic development and healing processes. However, DNA damage and oxidative stress that occur during aging cause the accumulation of senescent cells, which through their SASP bring about deleterious effects on multiple organ and systemic functions. Ablation of senescent cells through genetic or pharmacological means leads to improved life span and health span in animal models, and preliminary evidence suggests it may also have a positive impact on human health. Thus, strategies to reduce or eliminate the burden of senescent cells or their products have the potential to impact multiple clinical outcomes with a single intervention. In this review, we touch upon the basics of cell senescence and summarize the current state of development of therapies against cell senescence for human use.
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spelling pubmed-71407572020-04-14 Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review Amaya-Montoya, Mateo Pérez-Londoño, Agustín Guatibonza-García, Valentina Vargas-Villanueva, Andrea Mendivil, Carlos O. Adv Ther Review Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell cycle arrest with suppressed apoptosis and concomitant secretion of multiple bioactive factors (the senescence-associated secretory phenotype—SASP) that plays a physiological role in embryonic development and healing processes. However, DNA damage and oxidative stress that occur during aging cause the accumulation of senescent cells, which through their SASP bring about deleterious effects on multiple organ and systemic functions. Ablation of senescent cells through genetic or pharmacological means leads to improved life span and health span in animal models, and preliminary evidence suggests it may also have a positive impact on human health. Thus, strategies to reduce or eliminate the burden of senescent cells or their products have the potential to impact multiple clinical outcomes with a single intervention. In this review, we touch upon the basics of cell senescence and summarize the current state of development of therapies against cell senescence for human use. Springer Healthcare 2020-03-17 2020 /pmc/articles/PMC7140757/ /pubmed/32185730 http://dx.doi.org/10.1007/s12325-020-01287-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Amaya-Montoya, Mateo
Pérez-Londoño, Agustín
Guatibonza-García, Valentina
Vargas-Villanueva, Andrea
Mendivil, Carlos O.
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
title Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
title_full Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
title_fullStr Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
title_full_unstemmed Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
title_short Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
title_sort cellular senescence as a therapeutic target for age-related diseases: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140757/
https://www.ncbi.nlm.nih.gov/pubmed/32185730
http://dx.doi.org/10.1007/s12325-020-01287-0
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