Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches

The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these prog...

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Autores principales: Sánchez-González, Rebeca, Figueres-Oñate, María, Ojalvo-Sanz, Ana Cristina, López-Mascaraque, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140809/
https://www.ncbi.nlm.nih.gov/pubmed/32183100
http://dx.doi.org/10.3390/genes11030305
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author Sánchez-González, Rebeca
Figueres-Oñate, María
Ojalvo-Sanz, Ana Cristina
López-Mascaraque, Laura
author_facet Sánchez-González, Rebeca
Figueres-Oñate, María
Ojalvo-Sanz, Ana Cristina
López-Mascaraque, Laura
author_sort Sánchez-González, Rebeca
collection PubMed
description The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their molecular profiles remain unknown. Using modified StarTrack genetic tracing strategies, specific SVZ progenitor cells were targeted in E12 mice embryos, and the cell fate of these neural progenitors was determined in the adult olfactory bulb. This study defined the distribution and the phenotypic diversity of olfactory bulb interneurons from specific SVZ-progenitor cells, focusing on their spatial pallial origin, heterogeneity, and genetic profile.
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spelling pubmed-71408092020-04-10 Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches Sánchez-González, Rebeca Figueres-Oñate, María Ojalvo-Sanz, Ana Cristina López-Mascaraque, Laura Genes (Basel) Article The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their molecular profiles remain unknown. Using modified StarTrack genetic tracing strategies, specific SVZ progenitor cells were targeted in E12 mice embryos, and the cell fate of these neural progenitors was determined in the adult olfactory bulb. This study defined the distribution and the phenotypic diversity of olfactory bulb interneurons from specific SVZ-progenitor cells, focusing on their spatial pallial origin, heterogeneity, and genetic profile. MDPI 2020-03-13 /pmc/articles/PMC7140809/ /pubmed/32183100 http://dx.doi.org/10.3390/genes11030305 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-González, Rebeca
Figueres-Oñate, María
Ojalvo-Sanz, Ana Cristina
López-Mascaraque, Laura
Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches
title Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches
title_full Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches
title_fullStr Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches
title_full_unstemmed Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches
title_short Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches
title_sort cell progeny in the olfactory bulb after targeting specific progenitors with different ubc-startrack approaches
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140809/
https://www.ncbi.nlm.nih.gov/pubmed/32183100
http://dx.doi.org/10.3390/genes11030305
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