Cargando…

Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer

Germline variants in DNA repair genes are associated with aggressive prostate cancer (PrCa). The aim of this study was to characterize germline variants in DNA repair genes associated with lethal PrCa in Finnish and Swedish populations. Whole-exome sequencing was performed for 122 lethal and 60 unse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rantapero, Tommi, Wahlfors, Tiina, Kähler, Anna, Hultman, Christina, Lindberg, Johan, Tammela, Teuvo L. J., Nykter, Matti, Schleutker, Johanna, Wiklund, Fredrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140841/ https://www.ncbi.nlm.nih.gov/pubmed/32183364 http://dx.doi.org/10.3390/genes11030314

Ejemplares similares

MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families
por: Fischer, Daniel, et al.
Publicado: (2015)

Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer
por: Sjöblom, Liisa, et al.
Publicado: (2016)

ARLTS1 and Prostate Cancer Risk - Analysis of Expression and Regulation
por: Siltanen, Sanna, et al.
Publicado: (2013)

PALB2 variants in hereditary and unselected Finnish Prostate cancer cases
por: Pakkanen, Sanna, et al.
Publicado: (2009)

NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene
por: Mattila, Henna, et al.
Publicado: (2011)

Contribution of ARLTS1 Cys148Arg (T442C) Variant with Prostate Cancer Risk and ARLTS1 Function in Prostate Cancer Cells
por: Siltanen, Sanna, et al.
Publicado: (2011)

Assessing Interactions of Two Loci (rs4242382 and rs10486567) in Familial Prostate Cancer: Statistical Evaluation of Epistasis
por: Chen, Li-Sheng, et al.
Publicado: (2014)

Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer
por: Bova, G. Steven, et al.
Publicado: (2016)

ANO7 is associated with aggressive prostate cancer
por: Kaikkonen, Elina, et al.
Publicado: (2018)

Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease
por: Sipeky, Csilla, et al.
Publicado: (2021)

Prostate cancer risk prediction using a polygenic risk score
por: Sipeky, Csilla, et al.
Publicado: (2020)

The expression of AURKA is androgen regulated in castration-resistant prostate cancer
por: Kivinummi, Kati, et al.
Publicado: (2017)

Adaptive and non-adaptive gene expression responses in prostate cancer during androgen deprivation
por: Nätkin, Reetta, et al.
Publicado: (2023)

Epigenetically altered miR-193b targets cyclin D1 in prostate cancer
por: Kaukoniemi, Kirsi M, et al.
Publicado: (2015)

Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression
por: Latonen, Leena, et al.
Publicado: (2018)

Antihypertensive drug use and prostate cancer-specific mortality in Finnish men
por: Siltari, Aino, et al.
Publicado: (2020)

Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation
por: Viiri, Leena E., et al.
Publicado: (2019)

Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases
por: Kallio, Heini M. L., et al.
Publicado: (2018)

Prostate cancer incidence in men with prostate‐specific antigen below 3 ng/mL: The Finnish Randomized Study of Screening for Prostate Cancer
por: Ola, Idris Olasunmbo, et al.
Publicado: (2022)

Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases
por: Sattari, Mina, et al.
Publicado: (2023)

Inherited DNA-repair gene mutations in African American men with prostate cancer
por: Sartor, Oliver, et al.
Publicado: (2020)

The Importance of LDL and Cholesterol Metabolism for Prostate Epithelial Cell Growth
por: Murtola, Teemu J., et al.
Publicado: (2012)

Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer
por: Talala, Kirsi, et al.
Publicado: (2020)

Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine
por: Jasu, Juho, et al.
Publicado: (2021)

Psychological recovery and well-being of spouses of patients with prostate cancer 5 years after primary treatment in Finland: a follow-up survey
por: Lehto, Ulla-Sisko, et al.
Publicado: (2023)

Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer
por: Annala, Matti, et al.
Publicado: (2015)

Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC
por: Pashayan, Nora, et al.
Publicado: (2015)

Improved renal cancer prognosis among users of drugs targeting renin-angiotensin system
por: Eskelinen, Tommi, et al.
Publicado: (2021)

Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish
por: Saralahti, Anni K., et al.
Publicado: (2023)

DNA Repair Pathways and Their Association With Lethal Prostate Cancer in African American and European American Men
por: Plym, Anna, et al.
Publicado: (2021)

C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk
por: Eklund, C M, et al.
Publicado: (2009)

Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial
por: Raittinen, Paavo V.H., et al.
Publicado: (2021)

The expanded prostate cancer index composite short form (EPIC-26) for measuring health-related quality of life: content analysis of patients’ spontaneous comments written in survey margins
por: Talvitie, Anna-Maija, et al.
Publicado: (2021)

Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer
por: Ampuja, M., et al.
Publicado: (2017)

Cancer mortality does not differ by antiarrhythmic drug use: A population-based cohort of Finnish men
por: Kaapu, Kalle J., et al.
Publicado: (2018)

Digoxin and prostate cancer survival in the Finnish Randomized Study of Screening for Prostate Cancer
por: Kaapu, Kalle J, et al.
Publicado: (2016)

The Evolutionary History of Lethal Metastatic Prostate Cancer
por: Gundem, Gunes, et al.
Publicado: (2015)

Prostate cancer-specific survival among warfarin users in the Finnish Randomized Study of Screening for Prostate Cancer
por: Kinnunen, Pete T. T., et al.
Publicado: (2017)

Non-Steroidal Anti-Inflammatory Drugs and Cancer Death in the Finnish Prostate Cancer Screening Trial
por: Veitonmäki, Thea, et al.
Publicado: (2016)

Missingness in the expanded prostate cancer index short form (EPIC-26) – prevalence, patterns, and explanatory factors
por: Talvitie, Anna-Maija, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fc5i0fi87qt7u0f13pprl9o5js