The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation

NF-YA, the regulatory subunit of the trimeric transcription factor (TF) NF-Y, is regulated by alternative splicing (AS) generating two major isoforms, “long” (NF-YAl) and “short” (NF-YAs). Muscle cells express NF-YAl. We ablated exon 3 in mouse C2C12 cells by a four-guide CRISPR/Cas9n strategy, obta...

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Detalles Bibliográficos
Autores principales: Libetti, Debora, Bernardini, Andrea, Sertic, Sarah, Messina, Graziella, Dolfini, Diletta, Mantovani, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140862/
https://www.ncbi.nlm.nih.gov/pubmed/32214056
http://dx.doi.org/10.3390/cells9030789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140862/
https://www.ncbi.nlm.nih.gov/pubmed/32214056
http://dx.doi.org/10.3390/cells9030789

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